The First Affiliated Hospital of Harbin Medical University, No 23 Youzheng Street, Nangang District, Harbin, China.
Harbin Children's Hospital affiliated to Harbin Medical University, Harbin, China.
J Int Med Res. 2022 Aug;50(8):3000605221115389. doi: 10.1177/03000605221115389.
This study aimed to investigate the correlation between obstructive sleep apnoea (OSA) and the severity of coronary artery disease (CAD) assessed by angiography.
This prospective study screened 273 patients diagnosed with CAD by coronary angiography. The severity of CAD was assessed by SYNTAX score. A total of 255 subjects were enrolled of whom 161 were diagnosed with OSA, with an apnoea-hypopnoea index ≥5/hour. Ninety-four CAD patients without OSA were used as controls. The relationship between OSA and CAD was analysed by multiple linear regression.
The prevalence of OSA in CAD patients was 63.1%. The prevalences of single-vessel, two-vessel, and three-vessel disease were similar in the two groups. However, CAD was significantly more severe in patients with OSA, measured by SYNTAX score, than in those without OSA. OSA was independently associated with CAD after adjusting for traditional risk factors.
OSA is relatively common among patients with CAD in China. The independent association between OSA and CAD, even after adjusting for traditional confounders, suggests that OSA should be taken into account when considering the risk factors for CAD. The present findings highlight the important adverse influence of OSA on the severity of CAD.
本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）与冠状动脉疾病（CAD）严重程度之间的相关性，该严重程度通过血管造影进行评估。
这项前瞻性研究筛查了 273 名经冠状动脉造影诊断为 CAD 的患者。CAD 的严重程度通过 SYNTAX 评分进行评估。共纳入 255 名受试者，其中 161 名被诊断为 OSA，呼吸暂停低通气指数≥5/小时。94 名无 OSA 的 CAD 患者作为对照组。通过多元线性回归分析 OSA 与 CAD 之间的关系。
CAD 患者中 OSA 的患病率为 63.1%。两组中单支血管、双支血管和三支血管疾病的患病率相似。然而，与无 OSA 的患者相比，OSA 患者的 CAD 严重程度更高，这一结果通过 SYNTAX 评分来衡量。在调整传统危险因素后，OSA 与 CAD 独立相关。
OSA 在我国 CAD 患者中较为常见。OSA 与 CAD 之间的独立关联，即使在调整了传统混杂因素后，提示在考虑 CAD 的危险因素时应考虑 OSA。本研究结果强调了 OSA 对 CAD 严重程度的重要不利影响。
