由D-(+)-阿拉伯糖醇正式合成4-二磷酸胞苷-2-C-甲基-D-赤藓糖醇
Formal Synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol From D-(+)-Arabitol.
作者信息
Odejinmi Sina I, Rascon Rafael G, Chen Wyman, Lai Kent
机构信息
Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84132, U.S.A.
出版信息
Tetrahedron. 2012 Oct 28;68(43):8937-8941. doi: 10.1016/j.tet.2012.08.020.
2-C-methyl-D-erythritol-4-phosphate (MEP) is a key chemical intermediate of the non-mevalonate pathway for isoprenoid biosynthesis employed by many pathogenic microbes. MEP is also the precursor for the synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol (CDP-ME), another key intermediate of the non-mevalonate pathway. As this pathway is non-existent in higher animals, including humans, it represents great opportunities for novel antimicrobial development. To facilitate the in-depth studies of this pathway, we reported here a formal synthesis of CDP-ME through a new synthesis of 2-C-Methyl-D-erythritol-4-phosphoric acid from D-(+)-arabitol.
2-C-甲基-D-赤藓糖醇-4-磷酸（MEP）是许多致病微生物用于类异戊二烯生物合成的非甲羟戊酸途径的关键化学中间体。MEP也是合成4-二磷酸胞苷-2-C-甲基-D-赤藓糖醇（CDP-ME）的前体，CDP-ME是非甲羟戊酸途径的另一个关键中间体。由于该途径在包括人类在内的高等动物中不存在，它为新型抗菌药物的开发提供了巨大机遇。为了促进对该途径的深入研究，我们在此报告了通过从D-(+)-阿拉伯糖醇新合成2-C-甲基-D-赤藓糖醇-4-磷酸来正式合成CDP-ME。
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