Craver Randall, Arcement Christopher, Chrisentery Singleton Tammuella
Department of Pathology, Louisiana State University School of Medicine, New Orleans, LA ; Children's Hospital, New Orleans, LA.
Ochsner J. 2012 Fall;12(3):244-8.
A 7-year-old boy was treated with radiation and chemotherapy for a diffuse pontine glioma. At autopsy, 8 months after diagnosis, the tumor was a diffuse grade II fibrillary astrocytoma with prominent lipocytic differentiation. Literature review suggests that lipocytic differentiation in low-grade astrocytomas occurs in a variety of patient ages, anatomic sites, grades, and astrocytic subtypes. Although the majority of low-grade lipoastrocytomas have behaved benignly, this child's lipoastrocytoma was the underlying cause of death. This outcome suggests that the outcomes of low-grade lipoastrocytic tumors may be expected to be the same as the underlying tumor subtype.
一名7岁男孩因弥漫性脑桥胶质瘤接受了放疗和化疗。诊断8个月后进行尸检，肿瘤为弥漫性II级纤维型星形细胞瘤，伴有显著的脂肪细胞分化。文献综述表明，低级别星形细胞瘤中的脂肪细胞分化发生在不同的患者年龄、解剖部位、级别和星形细胞亚型中。虽然大多数低级别脂肪星形细胞瘤表现为良性，但该患儿的脂肪星形细胞瘤是死亡的根本原因。这一结果表明，低级别脂肪星形细胞瘤的预后可能与潜在的肿瘤亚型相同。
