Gheri Chiara Francesca, Buccoliero Anna Maria, Pansini Gastone, Castiglione Francesca, Garbini Francesca, Moncini Daniela, Maccari Cecilia, Mennonna Pasquale, Pellicanò Gianni, Ammannati Franco, Taddei Gian Luigi
Department of Human Pathology and Oncology, University of Florence,Units of Neurosurgery andNeuroradiology, Careggi Hospital, Florence, Italy.
Neuropathology. 2010 Oct;30(5):553-8. doi: 10.1111/j.1440-1789.2009.01096.x.
Lipoastrocytoma is an extremely rare tumor, with only six cases described. We report the case of an astrocytoma involving the upper part of the cerebellar-pontine angle and the right portion of the clivus starting from the brainstem with a diffuse lipomatous component in a 39 year-old man. The patient was admitted with headache of 1 year's duration and diplopia over the previous 3 months. MRI revealed a ponto-cerebellar lesion that showed irregular enhancement after contrast administration. Subtotal excision of the tumor was accomplished. Adjuvant chemotherapy and radiation therapy were not administered. Histologically the tumor showed the classical histology of low-grade astrocytoma and a portion of the lesion was composed of lipid-laden cells. Immunohistochemistry for glial fibrillary acid and S-100 proteins clearly demonstrated the glial nature of these cells. Ki-67/Mib-1 labeling index was low (2%). The patient remains in good neurological conditions after 10 months. Our case has a benign postoperative behavior, also after subtotal excision, with restrictions due to the short follow-up. It is important to record each new case of this rare tumor to produce a better characterization of this lesion.
脂肪星形细胞瘤是一种极为罕见的肿瘤，仅有6例病例报道。我们报告一例39岁男性患者，其星形细胞瘤累及脑桥小脑角上部和斜坡右侧，起源于脑干，伴有弥漫性脂肪成分。患者因持续1年的头痛及前3个月的复视而入院。磁共振成像（MRI）显示脑桥小脑病变，增强扫描后呈不规则强化。肿瘤行次全切除。未给予辅助化疗和放疗。组织学上，肿瘤表现为低级别星形细胞瘤的典型组织学特征，病变的一部分由充满脂质的细胞组成。胶质纤维酸性蛋白和S-100蛋白的免疫组化清楚地证实了这些细胞的胶质性质。Ki-67/Mib-1标记指数较低（2%）。10个月后患者神经状况良好。我们的病例术后行为良性，即使是次全切除后，由于随访时间短，仍有局限性。记录这种罕见肿瘤的每一例新病例对于更好地描述该病变很重要。
