Sivaraju Laxminadh, Aryan Saritha, Ghosal Nandita, Hegde Alangar S
1 Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bangalore, India.
2 Department of Pathology, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bangalore, India.
Neuroradiol J. 2018 Feb;31(1):32-38. doi: 10.1177/1971400917710667. Epub 2017 Jun 23.
Lipidized tumors of the central nervous system are very uncommon, with only a few cases described. We report a case of a 25-year-old woman with a tumor involving the left premotor area. She underwent gross total excision. Histologically, the tumor was composed of glial fibrillary acidic protein-positive glial cells with areas of lipidization. A diagnosis of lipoastrocytoma was rendered. At three-year follow-up she was doing well, supporting the presumed favorable prognosis of these uncommon tumors. Absence of xanthochromic appearance, mitotic activity, necrosis and poor reticulin activity are the differentiating features from the pleomorphic xanthoastrocytoma. We highlighted that these tumors involve the adult and pediatric population and distribute in both supratentorial and infratentorial compartments as well as in the spinal cord.
中枢神经系统的脂质化肿瘤非常罕见，仅有少数病例被描述。我们报告一例25岁女性，其肿瘤累及左前运动区。她接受了肿瘤全切术。组织学上，肿瘤由胶质纤维酸性蛋白阳性的胶质细胞组成，并伴有脂质化区域。诊断为脂肪星形细胞瘤。三年随访时她情况良好，支持这些罕见肿瘤预后可能良好的推测。无黄变外观、有丝分裂活性、坏死及网硬蛋白活性差是与多形性黄色星形细胞瘤的鉴别特征。我们强调这些肿瘤累及成人和儿童人群，分布于幕上和幕下腔隙以及脊髓。
