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Metergoline abolishes the prolactin response to buspirone.

作者信息

Gregory C A, Anderson I M, Cowen P J

机构信息

MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.

出版信息

Psychopharmacology (Berl). 1990;100(2):283-4. doi: 10.1007/BF02244420.

DOI:10.1007/BF02244420
PMID:2305017
Abstract

Pretreatment of nine healthy subjects with the non-selective 5-HT receptor antagonist, metergoline (4 mg), abolished the increase in plasma prolactin produced by the anxiolytic drug, buspirone (15 mg). While these findings are consistent with a role for 5-HT receptors in the stimulatory effect of buspirone on plasma prolactin, a dopaminergic mechanism cannot be excluded by the present data.

摘要

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1
Metergoline abolishes the prolactin response to buspirone.
Psychopharmacology (Berl). 1990;100(2):283-4. doi: 10.1007/BF02244420.
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本文引用的文献

1
Effects of methergoline on central monoamine neurones. Evidence for a selective blockade of central 5-HT receptors.麦角新碱对中枢单胺能神经元的作用。中枢5-羟色胺受体选择性阻断的证据。
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On the mode of the prolactin release-inhibiting action of the serotonin receptor blockers metergoline, methysergide, and cyproheptadine.关于血清素受体阻滞剂美替拉酮、甲基麦角新碱和赛庚啶的催乳素释放抑制作用方式。
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Comparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release.
病毒性疲劳综合征患者下丘脑5-羟色胺受体可能上调。
BMJ. 1992 Apr 18;304(6833):1010-2. doi: 10.1136/bmj.304.6833.1010.
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Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers.
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5-HT1和5-HT2结合位点的药理学特性与调节5-羟色胺释放的5-羟色胺自身受体药理学特性的比较。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(3):165-70. doi: 10.1007/BF00505480.
4
The effect of buspirone on prolactin and growth hormone secretion in man.丁螺环酮对人体催乳素和生长激素分泌的影响。
Arch Gen Psychiatry. 1983 Oct;40(10):1099-102. doi: 10.1001/archpsyc.1983.01790090061009.
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Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications.降低和释放催乳素的药物。作用机制及治疗应用。
Drugs. 1983 Apr;25(4):399-432. doi: 10.2165/00003495-198325040-00004.
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Dopamine receptor antagonism by the novel antianxiety drug, buspirone.新型抗焦虑药物丁螺环酮对多巴胺受体的拮抗作用。
J Neurosci. 1983 Apr;3(4):733-8. doi: 10.1523/JNEUROSCI.03-04-00733.1983.
7
Effect of buspirone on rat plasma prolactin levels and striatal dopamine turnover.丁螺环酮对大鼠血浆催乳素水平及纹状体多巴胺代谢的影响。
Psychopharmacology (Berl). 1982;78(1):49-53. doi: 10.1007/BF00470587.
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Investigation of the abuse liability of buspirone in alcohol-dependent patients.
Am J Med. 1986 Mar 31;80(3B):30-5. doi: 10.1016/0002-9343(86)90329-3.
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Serum prolactin levels after buspirone in man.人服用丁螺环酮后的血清催乳素水平。
Med Biol. 1987;65(1):61-3.
10
Further studies of the putative serotonin agonist, m-chlorophenylpiperazine: evidence for a serotonin receptor mediated mechanism of action in humans.
Psychopharmacology (Berl). 1986;89(3):388-91. doi: 10.1007/BF00174380.