Seppälä T, Ranta T, Shrotriya R C
Med Biol. 1987;65(1):61-3.
The acute effects of buspirone, an anxiolytic with mixed dopamine (DA) agonist-antagonist properties (achieved by blocking pre- and postsynaptic receptors) on serum prolactin (PRL) were studied in cross-over and double-blind trials in ten healthy young males. Sulpiride (200 mg) was used as a control drug; it raised PRL by almost 800%. Buspirone (25, 50 and 100 mg) raised serum PRL dose-dependently; the greatest increases (30, 70, and 320% from baseline, respectively) were seen 1 h after each dose. The results suggest that buspirone blocks postsynaptic DA receptors only at doses higher than those needed for anxiolysis.
在一项针对10名健康年轻男性的交叉双盲试验中，研究了丁螺环酮（一种具有混合多巴胺（DA）激动剂-拮抗剂特性的抗焦虑药，通过阻断突触前和突触后受体实现）对血清催乳素（PRL）的急性影响。舒必利（200mg）用作对照药物；它使PRL升高了近800%。丁螺环酮（25mg、50mg和100mg）使血清PRL呈剂量依赖性升高；每次给药后1小时出现最大升高（分别比基线升高30%、70%和320%）。结果表明，丁螺环酮仅在高于抗焦虑所需剂量时才会阻断突触后DA受体。
