Atkinson D J, Burstein D, Edelman R R
Department of Radiology, Beth Israel Hospital, Boston, MA 02215.
Radiology. 1990 Mar;174(3 Pt 1):757-62. doi: 10.1148/radiology.174.3.2305058.
The authors studied cardiac perfusion by administering gadolinium diethylenetriaminepentaacetic acid (DTPA) in conjunction with an ultrafast imaging technique that produces strongly T1-weighted images. The method consisted of a 180 degrees inversion pulse, followed by a gradient-echo acquisition with a very short repetition time (less than 4 msec). Each image was acquired throughout a small fraction of the cardiac cycle. The method was applied in an isolated perfused rat heart model (acquisition time = 116 msec) and in human subjects without known cardiac disease (acquisition time = 125 msec). Fast, high-resolution images (128 X 128 matrix) were created by combining sequentially acquired small matrixes. After bolus administration of Gd-DTPA in the perfused rat heart model, contrast was pronounced between the nonperfused myocardium and perfused normal myocardium. First-pass wash-in and washout phases of the contrast material were observed in the perfused rat heart model and in human subjects. Results demonstrated the clinical feasibility of first-pass perfusion studies of the heart. The studies can be performed on a conventional whole-body imaging system with standard hardware.
作者通过给予钆喷酸葡胺（DTPA）并结合一种能产生强T1加权图像的超快成像技术来研究心脏灌注。该方法包括一个180度反转脉冲，随后是一个重复时间非常短（小于4毫秒）的梯度回波采集。每个图像在心动周期的一小部分时间内采集。该方法应用于离体灌注大鼠心脏模型（采集时间 = 116毫秒）和无已知心脏病的人体受试者（采集时间 = 125毫秒）。通过依次组合采集的小矩阵创建快速、高分辨率图像（128×128矩阵）。在灌注大鼠心脏模型中静脉推注钆喷酸葡胺后，未灌注心肌与灌注正常心肌之间的对比明显。在灌注大鼠心脏模型和人体受试者中观察到了对比剂的首过注入和洗脱阶段。结果证明了心脏首过灌注研究的临床可行性。这些研究可以在配备标准硬件的传统全身成像系统上进行。
