Johannessen S I
National Center for Epilepsy, Sandvika, Norvège.
Rev Prat. 1990 Feb 1;40(4):319-22.
Drug assays play an important role in the control of antiepileptic treatment because the relationship between the serum concentration of an active drug and its therapeutic effects and side-effects is closer than between dose and effect. Bioavailability, protein binding and drug elimination are subject to inter- and intraindividual variations. However, it is important to remember that the optimal therapeutic ranges reported for serum levels are only a guideline to drug therapy. It is the patient who must be treated and not the serum level.
药物测定在抗癫痫治疗的控制中起着重要作用，因为活性药物的血清浓度与其治疗效果和副作用之间的关系比剂量与效果之间的关系更为密切。生物利用度、蛋白结合和药物消除存在个体间和个体内差异。然而，重要的是要记住，所报道的血清水平的最佳治疗范围只是药物治疗的一个指导原则。必须治疗的是患者，而不是血清水平。
