白细胞介素-1 基因多态性与多发性硬化症的关联：荟萃分析。
Association of interleukin-1 gene polymorphisms with multiple sclerosis: a meta-analysis.
机构信息
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, People's Republic of China.
出版信息
Inflamm Res. 2013 Jan;62(1):97-106. doi: 10.1007/s00011-012-0556-1. Epub 2012 Oct 4.
BACKGROUND
Dysregulated levels of interleukin-1 (IL-1) were observed in patients with multiple sclerosis (MS). Previous studies have provided conflicting evidence implicating the IL-1 gene polymorphisms in MS risk.
METHODS
A meta-analysis of 16 case-control studies involving 3,482 cases and 3,528 controls was conducted to evaluate this association.
RESULTS
No association was found between the IL-1α -889 (rs1800587), IL-1α +4,845 (rs17561), IL-1β -511 (rs16944), IL-1β +3,953 (rs1143634), IL-1ra variable number tandem repeat (VNTR) polymorphisms and MS risk. However, in subgroup analyses for the IL-1ra VNTR polymorphism, we found that individuals carrying the 2 allele had a 32 % increased risk for bout-onset MS (relapsing remitting and secondary progressive MS) when compared to the LL homozygotes (OR = 1.32, 95 % CI = 1.06-1.66, P (z) = 0.014).
CONCLUSION
Common variants in the IL-1 region are not associated with MS risk but our data suggest that the IL-1ra VNTR polymorphism might be associated with bout-onset MS subtype.
背景
多发性硬化症（MS）患者的白细胞介素-1（IL-1）水平失调。先前的研究提供了相互矛盾的证据，表明 IL-1 基因多态性与 MS 风险有关。
方法
对 16 项病例对照研究进行了荟萃分析，共纳入 3482 例病例和 3528 例对照，以评估这种关联。
结果
IL-1α-889（rs1800587）、IL-1α+4845（rs17561）、IL-1β-511（rs16944）、IL-1β+3953（rs1143634）和 IL-1ra 可变数目串联重复（VNTR）多态性与 MS 风险之间均无关联。然而，在 IL-1ra VNTR 多态性的亚组分析中，我们发现与 LL 纯合子相比，携带 2 等位基因的个体发生发作性 MS（复发缓解型和继发性进展型 MS）的风险增加了 32%（OR=1.32，95%CI=1.06-1.66，P（z）=0.014）。
结论
IL-1 区域的常见变异与 MS 风险无关，但我们的数据表明，IL-1ra VNTR 多态性可能与发作性 MS 亚型有关。
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