Dincić Evica, Zivković Maja, Stanković Aleksandra, Obradović Dragana, Alavantić Dragan, Kostić Vladimir, Raicević Ranko
Department of Neurology, Military Medical Academy, Belgrade, Serbia and Montenegro.
J Neuroimmunol. 2006 Aug;177(1-2):146-50. doi: 10.1016/j.jneuroim.2006.05.005.
We have investigated separate as well as combined influence of IL-1beta TaqI, IL-1ra VNTR and CTLA-4 + 49 A/G polymorphisms on susceptibility, clinical course and progression of MS in 162 Serbian patients. We found significant independent relative risk for MS susceptibility in noncarriers of IL-1ra allele 2 (OR = 2.2, CI = 1.3-3.7, p = 0.003) and CTLA-4 + 49 AA genotype (OR = 2.0, CI = 1.2-3.5, p = 0.01) as well as their combined effect (OR = 4.4, CI = 2.0-9.7, p = 0.0003). Our result supports the significant and combined effect of IL-1ra VNTR and CTLA-4 polymorphisms on MS justifying the need for further haplotype analysis in different populations.
我们研究了白细胞介素-1β TaqI、白细胞介素-1受体拮抗剂可变数目串联重复序列（IL-1ra VNTR）以及细胞毒性T淋巴细胞相关抗原4（CTLA-4）+49 A/G多态性对162例塞尔维亚患者多发性硬化症（MS）易感性、临床病程及病情进展的单独及联合影响。我们发现，在白细胞介素-1受体拮抗剂等位基因2的非携带者（比值比[OR]=2.2，可信区间[CI]=1.3 - 3.7，p=0.003）和CTLA-4 + 49 AA基因型（OR=2.0，CI=1.2 - 3.5，p=0.01）中，MS易感性存在显著的独立相对风险，以及它们的联合效应（OR=4.4，CI=2.0 - 9.7，p=0.0003）。我们的结果支持白细胞介素-1受体拮抗剂可变数目串联重复序列和CTLA-4多态性对MS的显著联合效应，证明了在不同人群中进行进一步单倍型分析的必要性。
