Kushner M J
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Stroke. 1990 Feb;21(2):295-8. doi: 10.1161/01.str.21.2.295.
Over 2 years, 104 patients underwent clinical evaluation and laboratory screening for the presence of abnormal anticardiolipin antibodies to determine the profile of laboratory and clinical findings in patients with stroke and other neurologic disorders. Seven with incomplete or ambiguous data were excluded; of the remaining 97 patients, 31 were greater than or equal to 65 years old. Nine patients suffered systemic lupus erythematosus, 45 suffered brain ischemia, and 43 suffered other nonischemic neurologic disorders. Cardiac arrhythmia, myocardial infarction, and cardiac valvulopathy were grounds for exclusion. The presence of anticardiolipin antibodies was not influenced by age. In the 88 patients without lupus, anticardiolipin antibodies were significantly more common in the group suffering brain ischemia than in the group with nonischemic neurologic disorders (29% versus 5%, p less than 0.01, chi 2 test). These controlled data demonstrate an association between the presence of circulating anticardiolipin antibodies with stroke, but not with other neurologic conditions.
在两年多的时间里，104名患者接受了临床评估和实验室筛查，以检测是否存在异常抗心磷脂抗体，从而确定中风及其他神经系统疾病患者的实验室检查结果和临床表现特征。排除了7名数据不完整或不明确的患者；在其余97名患者中，31名年龄大于或等于65岁。9名患者患有系统性红斑狼疮，45名患者患有脑缺血，43名患者患有其他非缺血性神经系统疾病。患有心律失常、心肌梗死和心脏瓣膜病的患者被排除在外。抗心磷脂抗体的存在不受年龄影响。在88名无狼疮的患者中，脑缺血组抗心磷脂抗体的出现明显比非缺血性神经系统疾病组更为常见（29%对5%，p<0.01，卡方检验）。这些对照数据表明循环抗心磷脂抗体的存在与中风有关，但与其他神经系统疾病无关。
