Bhandari Abhishek, Crowe Sheila E
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0063, USA.
Curr Gastroenterol Rep. 2012 Dec;14(6):489-96. doi: 10.1007/s11894-012-0296-y.
Helicobacter pylori infection remains common worldwide and is significantly associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT)lymphoma. This article reviews recent developments in the field of H. pylori with an emphasis on mechanisms of carcinogenesis, and the bacterial, environmental and host factors that may alter risk of developing gastric cancer or gastric MALT lymphoma. The topic of eradication of H. pylori to prevent the development of malignancy and the possibility of a vaccine against H. pylori are also explored.
幽门螺杆菌感染在全球范围内仍然很常见，并且与胃腺癌和胃黏膜相关淋巴组织（MALT）淋巴瘤显著相关。本文综述了幽门螺杆菌领域的最新进展，重点关注致癌机制以及可能改变患胃癌或胃MALT淋巴瘤风险的细菌、环境和宿主因素。还探讨了根除幽门螺杆菌以预防恶性肿瘤发生的话题以及研发幽门螺杆菌疫苗的可能性。
