Department of Laboratory Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
Biol Trace Elem Res. 2012 Dec;150(1-3):91-102. doi: 10.1007/s12011-012-9509-3. Epub 2012 Oct 6.
In the present study, we evaluated the correlation between iron deficiency (ID) and zinc deficiency (ZD) and explored the demographic, anthropometric, and feeding-related factors associated with hypozincemia and hair zinc content in weaning infants. Infants aged 6-24 months were recruited, their feeding history was recorded, and their heights and weights were measured. Hemoglobin content, serum iron/total iron-binding capacity, and ferritin and zinc concentrations of serum and hair (using inductively coupled plasma-mass spectroscopy) were assessed. Among 101 infants, 64 (63.4 %) infants exhibited ID. The median serum zinc concentration in iron-deficient infants was lower than that in non-iron-deficient infants, respectively, 73.5 μg/dL (interquartile range [IQR], 65.0-83.8) vs. 87.0 μg/dL (IQR, 77.5-97.0; p = 0.001). The frequency of hypozincemia was also significantly higher in the iron-deficient group than in the non-iron-deficient group (21 out of 64 [32.8 %] vs. 4 out of 37 [10.8 %], respectively; p = 0.014). In multiple regression analysis, the risk of hypozincemia was significantly increased in infants with ID (p = 0.026), mildly underweight infants (weight-for-age Z score < -1; p = 0.034), and infants with mild wasting (weight-for-height Z score < -1; p = 0.028). Hair zinc concentrations (n = 81) were not significantly associated with ID status (p > 0.1); however, there was an inverse relationship between hair zinc concentrations and age of infants (r = -0.250; p = 0.024). In weaning infants, ID is a risk factor for hypozincemia. Hair zinc concentrations appeared to decrease as the age of infants increased during late infancy. Further large-scale studies are needed to validate the relationship between hypozincemia and mild degrees of weight gain impairment in this age group.
在本研究中，我们评估了铁缺乏（ID）和锌缺乏（ZD）之间的相关性，并探讨了与断奶婴儿低血锌和头发锌含量相关的人口统计学、人体测量学和喂养相关因素。招募了 6-24 个月大的婴儿，记录他们的喂养史，并测量他们的身高和体重。评估血红蛋白含量、血清铁/总铁结合能力以及血清和头发中的锌浓度（使用电感耦合等离子体质谱法）。在 101 名婴儿中，64 名（63.4%）婴儿存在 ID。铁缺乏婴儿的中位血清锌浓度低于非铁缺乏婴儿，分别为 73.5μg/dL（四分位距 [IQR]，65.0-83.8）和 87.0μg/dL（IQR，77.5-97.0；p=0.001）。铁缺乏组低血锌的发生率也明显高于非铁缺乏组（21 例 [32.8%] 比 4 例 [10.8%]，分别；p=0.014）。在多元回归分析中，ID 婴儿发生低血锌的风险显著增加（p=0.026），轻度体重不足婴儿（体重年龄 Z 评分<-1；p=0.034）和轻度消瘦婴儿（身高体重 Z 评分<-1；p=0.028）。头发锌浓度（n=81）与 ID 状态无显著相关性（p>0.1）；然而，头发锌浓度与婴儿年龄呈负相关（r=-0.250；p=0.024）。在断奶婴儿中，ID 是低血锌的危险因素。在婴儿后期，头发锌浓度似乎随着婴儿年龄的增长而降低。需要进一步的大规模研究来验证该年龄组低血锌与轻度体重增加受损之间的关系。
