Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Street, Detroit, MI 48201, USA.
J Natl Compr Canc Netw. 2012 Oct 1;10 Suppl 2(0 2):S56-9. doi: 10.6004/jnccn.2012.0177.
Direct lethal effects of photodynamic therapy (PDT) on a cell population were initially shown to occur via initiation of apoptosis, with high doses having a necrotic effect. Selective induction of cellular "self-digestion," better known as autophagy, represents a novel therapeutic target for the prevention of tumor growth and metastasis. It should be noted that autophagy has conflicting roles in the regulation of cell death, which, when applied to oncology, may produce both positive and negative effects on tumor development. Through better understanding the complex parts played by autophagy among diverse cellular signaling pathways in preclinical models, it may be possible to selectively regulate autophagy in response to specific stimuli, thereby inhibiting its oncogenic tendencies while preserving its tumor-suppressive capabilities.
光动力疗法（PDT）对细胞群体的直接致死作用最初被证明是通过启动细胞凋亡来实现的，高剂量则具有坏死作用。选择性诱导细胞“自我消化”，即众所周知的自噬，是预防肿瘤生长和转移的新的治疗靶点。需要指出的是，自噬在细胞死亡的调控中具有双重作用，将其应用于肿瘤学领域，可能对肿瘤的发展产生正反两方面的影响。通过更好地理解自噬在临床前模型中各种细胞信号通路中的复杂作用，有可能针对特定的刺激来选择性地调节自噬，从而抑制其致癌倾向，同时保留其肿瘤抑制能力。
