Servadio C, Leib Z, Lev A
Department of Urology, Beilinson Medical Center, Petah Tiqva, Israel.
Urology. 1990 Feb;35(2):156-63. doi: 10.1016/0090-4295(90)80067-w.
Repeated treatments of localized deep microwave hyperthermia were given to a series of dogs by means of a 915 MHz, water-cooled skirt-type applicator. The applicator was inserted into the rectum and directed toward the prostate in order to heat it by means of the absorbed microwaves while keeping the rectal wall at a lower temperature by surface cooling of the applicator itself. Sessions were given for different lengths of time ranging between ninety minutes and five hours, during which the prostate temperature was kept at 42.5 degrees C (+/- 0.5 degrees C) or 44.5 degrees C (+/- 0.5 degrees C). Three-dimensional temperature distributions in the prostate were measured accurately and verified by a Luxtron Fluoroptic Unit. Temperatures were constantly monitored in the rectal wall and in the prostatic urethra. Thorough and systemic follow-up was done before, during, and after each treatment, and the observations are reported. Two interesting preliminary observations were made: (1) differential blood counts showed significantly monocytosis following the treatments and lasted for at least one week, and (2) values of creatinine phosphokinase (CPK) and serum glutamic oxaloacetic transaminase (SGOT) were found to rise irreversibly in those animals which were later found to have definite histopathologic evidence of localized necrotic damage.
使用915兆赫兹水冷裙式辐射器对一系列犬进行局部深部微波热疗的重复治疗。将辐射器插入直肠并对准前列腺，以便通过吸收的微波加热前列腺，同时通过辐射器自身的表面冷却使直肠壁保持较低温度。治疗时间为90分钟至5小时不等，在此期间前列腺温度保持在42.5摄氏度（±0.5摄氏度）或44.5摄氏度（±0.5摄氏度）。用Luxtron荧光装置精确测量并验证前列腺内的三维温度分布。持续监测直肠壁和前列腺尿道的温度。在每次治疗前、治疗期间和治疗后进行全面系统的随访，并报告观察结果。有两项有趣的初步观察结果：（1）血细胞分类计数显示治疗后单核细胞增多明显，且持续至少一周；（2）在后来被发现有明确组织病理学证据表明存在局部坏死损伤的动物中，发现肌酸磷酸激酶（CPK）和血清谷氨酸草酰乙酸转氨酶（SGOT）的值不可逆地升高。
