Leib Z, Rothem A, Lev A, Servadio C
Prostate. 1986;8(1):93-102. doi: 10.1002/pros.2990080112.
A large series of repeated experiments were performed applying localized microwave hyperthermia to the prostate in dogs using a new water-cooled skirt-type antenna [1], operating at 915 MHz, as part of a new hyperthermia apparatus being developed for the treatment of the prostate in humans. The prostate gland of 20 male dogs was heated repeatedly under general anesthesia, at temperatures between 40 degrees C and 47 degrees C, and for different lengths of time up to 10 h. The prostate and other tissues were evaluated histopathologically following treatments. Invariably, all treatments by hyperthermia of the prostate caused a mononuclear inflammatory infiltration in the interstitium and polymorphonuclear infiltration in the glandular elements. Permanent tissue damage was found to be time-and temperature-dependent. Heating at 42.5 degrees C (+/- 0.5 degrees 5C) for up to 1.5 h was found to be harmless and could be safely repeated with our equipment. This study was part of a preclinical evaluation of a new antenna and apparatus.
使用一种新型水冷裙式天线[1]对犬前列腺进行局部微波热疗，该天线工作频率为915MHz，是正在研发的用于治疗人类前列腺疾病的新型热疗设备的一部分，在此基础上进行了一系列大量的重复实验。在全身麻醉下，对20只雄性犬的前列腺进行反复加热，温度在40摄氏度至47摄氏度之间，持续时间最长可达10小时。治疗后对前列腺和其他组织进行组织病理学评估。无一例外，所有前列腺热疗治疗均导致间质单核细胞炎性浸润和腺泡多形核细胞浸润。发现永久性组织损伤与时间和温度有关。发现在42.5摄氏度（±0.5摄氏度）下加热长达1.5小时是无害的，并且使用我们的设备可以安全地重复进行。本研究是对新型天线和设备进行临床前评估的一部分。
