Umanskiĭ V Iu, Balitskaia E K, Shmal'ko Iu P, Kas'ianenko I V
Vopr Onkol. 1990;36(1):13-7.
The influence of drugs improving sympathoadrenal system status on natural killer (NK) functional activity was studied in lung cancer patients. The activity of adenosine-metabolizing enzymes (adenosine deaminase and 5'-nucleotidase) in NK cells was found significantly altered, suggesting the involvement of this phenomenon in decreasing NK activity under tumor growth. Pharmacological correction of sympathoadrenal system status was followed by an increase in NK functional activity in lung cancer patients.
研究了改善交感肾上腺系统状态的药物对肺癌患者自然杀伤（NK）细胞功能活性的影响。发现NK细胞中腺苷代谢酶（腺苷脱氨酶和5'-核苷酸酶）的活性发生了显著变化，表明这种现象参与了肿瘤生长过程中NK活性的降低。对交感肾上腺系统状态进行药理纠正后，肺癌患者的NK功能活性增加。
