Jain Ritu, Mohamed Faizuddin, Hemalatha M
Department of Periodontics, Christian Dental College, Ludhiana, India.
J Indian Soc Periodontol. 2012 Apr;16(2):179-83. doi: 10.4103/0972-124X.99259.
The role of chemotherapeutic agents in periodontal therapy as adjuncts to mechanical debridement maybe justified by the inherent limitations of mechanical therapy. The aim of this study was to evaluate the long term efficacy of a locally delivered 2% minocycline gel as an adjunct to scaling and root planing in managing chronic periodontitis.
This was a randomized controlled trial using a split-mouth study design. Twenty two pairs of sites with similar probing depths were randomly allocated to test and control groups. All sites received thorough scaling and root planing followed by minocycline gel application in the test sites. Probing depths, relative attachment levels, plaque index, and microbiological parameters were evaluated for both the groups over a 9-month period.
Overall parameters improved from baseline in both the test and control groups. For most parameters, the differences between test and control groups were not significant at different time intervals. The probing depth values in the test group at six (3.64±0.83 mm) and nine months (3.81±0.79 mm) were significantly less than control group(4.24±0.95 mm at six and 4.63±0.94 mm at nine months), these differences being significant at P<0.05 and <0.01, respectively. At the end of nine months, the number of non-motile bacilli in test group (21.65±3.74) were significantly less than control group (25.5±3.01), the difference being significant at P<0.02.
The overall view of results in our investigation did not show any significant advantage of using 2% minocycline gel over scaling and root planning as an effective local drug delivery system and calls for further clinical trials to objectively evaluate its adjunctive in treatment of periodontitis.
由于机械治疗存在固有的局限性，化疗药物在牙周治疗中作为机械清创辅助手段的作用或许是合理的。本研究的目的是评估局部应用2%米诺环素凝胶作为慢性牙周炎龈下刮治和根面平整辅助治疗手段的长期疗效。
这是一项采用半口研究设计的随机对照试验。二十二对探诊深度相似的部位被随机分配到试验组和对照组。所有部位均接受彻底的龈下刮治和根面平整，试验组在此基础上应用米诺环素凝胶。在9个月的时间里，对两组的探诊深度、相对附着水平、菌斑指数和微生物学参数进行评估。
试验组和对照组的各项参数均较基线有所改善。对于大多数参数，试验组和对照组在不同时间间隔的差异并不显著。试验组在6个月（3.64±0.83毫米）和9个月（3.81±0.79毫米）时的探诊深度显著小于对照组（6个月时为4.24±0.95毫米，9个月时为4.63±0.94毫米），这些差异分别在P<0.05和P<0.
