Department of Prosthetic Dentistry, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
J Mater Sci Mater Med. 2013 Mar;24(3):659-66. doi: 10.1007/s10856-012-4825-x. Epub 2012 Dec 11.
Biodegradable polymers are compatible, permeable and nontoxic, thus they can provide a useful tool for drug delivery or tissue engineering. These polymers can form hydrogels, which are suitable vehicles for different types of materials e.g. drugs, bioactive molecules or cells. In the case of dentistry, photopolymerization is an obvious method to obtain in situ useable devices which can provide a more efficient way of tailoring drug release. A hydrogel system was developed based on poly-gamma-glutamic acid that was modified with methacryloyl groups to achieve this purpose. The resulting new reactive structure was proved by NMR spectroscopy. The swelling ratio of this type of hydrogel has been found remarkable, over 300 % after 24 h, and it can release 5 ng/mm(2) metronidazole. The prepared hydrogels were nontoxic as viability, cytotoxicity tests and cell morphology investigations proved it. These results render this model system an excellent candidate for use as an in situ curing local drug delivery device. The new photoactive system can be utilized in the treatment of periodontal diseases or raising the effectiveness of drugs used only in the minimal effective dose.
可生物降解聚合物具有相容性、可渗透性和低毒性，因此可为药物输送或组织工程提供有用的工具。这些聚合物可以形成水凝胶，是不同类型材料（例如药物、生物活性分子或细胞）的合适载体。在牙科领域，光聚合是获得可现场使用设备的一种明显方法，它可以提供一种更有效的定制药物释放方式。本研究基于聚-γ-谷氨酸，用丙烯酰基对其进行修饰，以达到这一目的，开发了一种水凝胶系统。通过核磁共振光谱证明了所得新反应性结构。这种水凝胶的溶胀率非常显著，24 小时后超过 300%，并能释放 5ng/mm(2)甲硝唑。通过细胞活力、细胞毒性试验和细胞形态学研究证明，所制备的水凝胶是无毒的。这些结果表明该模型系统非常适合用作原位固化局部药物输送装置。新型光活性系统可用于治疗牙周病或提高仅以最小有效剂量使用的药物的效果。
