Nadig Prasad Shyamrajan, Shah Monali Amit
Department of Periodontology, K.M. Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
J Indian Soc Periodontol. 2016 Nov-Dec;20(6):576-583. doi: 10.4103/jisp.jisp_97_17.
The aim of the present meta-analysis is to determine the efficacy of tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis.
MEDLINE, EBSCO, Cochrane database, and Google Scholar were used to identify studies in English published up to January 31, 2017. An additional hand search of relevant journals and of the bibliographies of the paper identified was also performed. Articles retrieved were screened using specific inclusion criteria by two independent reviewers. Randomized control trials investigating the effect of tetracycline group of antibiotics as local drug delivery agents in chronic periodontitis were included in the study.
Ten relevant articles were selected for the meta-analysis, of which five articles were retrieved after electronic search, three articles were included after hand search, and two unpublished articles were included. The number of patients in studies ranged from 13 to 140 sites with mean age ranging from 20 to 75. A total of 588 sites were treated using tetracycline group of antibiotics as local drug delivery agents in the treatment of chronic periodontitis. The meta-analysis showed standard difference in mean -1.02 mm (95% confidence interval [CI] 0.28, 1.75) for clinical gain in attachment in favor of tetracycline group. Standard difference in mean for probing depth (PD) was 1.20 mm (95% CI 0.57, 1.87) in tetracycline group.
The results of this meta-analysis showed a significant improvement in periodontal parameters such as CAL, PD, and sulcular bleeding index in favor of tetracycline as local drug delivery compared to placebo.
本荟萃分析的目的是确定四环素类抗生素作为局部给药制剂治疗慢性牙周炎的疗效。
使用MEDLINE、EBSCO、Cochrane数据库和谷歌学术搜索截至2017年1月31日发表的英文研究。还对手检相关期刊以及所识别论文的参考文献进行了额外检索。由两名独立评审员使用特定纳入标准对检索到的文章进行筛选。研究纳入了调查四环素类抗生素作为局部给药制剂治疗慢性牙周炎效果的随机对照试验。
选择了10篇相关文章进行荟萃分析，其中5篇文章是电子检索后获得的，3篇文章是手检后纳入的，2篇未发表文章也被纳入。各研究中的患者数量为13至140个位点，平均年龄为20至75岁。共有588个位点使用四环素类抗生素作为局部给药制剂治疗慢性牙周炎。荟萃分析显示，四环素组附着临床增益的平均标准差为-1.02 mm（95%置信区间[CI] 0.28，1.75）。四环素组探诊深度（PD）的平均标准差为1.20 mm（95% CI 0.57，1.87）。
本荟萃分析结果显示，与安慰剂相比，四环素作为局部给药制剂在牙周参数如临床附着丧失（CAL）、PD和龈沟出血指数方面有显著改善。
