产碳青霉烯酶肺炎克雷伯菌（KPC）的流行状况及威胁概述。
Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance.
机构信息
Duke Program for Infection Prevention and Healthcare Epidemiology, Durham, NC, USA ; Duke Infection Control Outreach Network, Durham, NC, USA ; Duke University Prevention Epicenter Program, Durham, NC, USA ; Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
出版信息
Infect Drug Resist. 2012;5:133-41. doi: 10.2147/IDR.S26613. Epub 2012 Sep 24.
Abstract
Klebsiella pneumoniae carbapenemases (KPCs) confer resistance to nearly all β-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-producing organisms.
摘要
肺炎克雷伯菌碳青霉烯酶（KPCs）赋予了对几乎所有β-内酰胺类药物的耐药性。这种广谱耐药机制在美国迅速传播，据报道在世界其他地方也在增加。因此，KPC 耐药性的出现对全球健康构成了重大威胁。本文综述了其流行病学，并概述了产 KPC 生物体的传播情况。
相似文献
1
Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance.产碳青霉烯酶肺炎克雷伯菌（KPC）的流行状况及威胁概述。
Infect Drug Resist. 2012;5:133-41. doi: 10.2147/IDR.S26613. Epub 2012 Sep 24.
2
Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods.产碳青霉烯酶肺炎克雷伯菌的全球传播：流行病学、基因背景、治疗选择及检测方法
Front Microbiol. 2016 Jun 13;7:895. doi: 10.3389/fmicb.2016.00895. eCollection 2016.
3
Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.碳青霉烯酶 2（KPC-2），在 Ambler 位置 Asp179 的取代以及对头孢他啶-阿维巴坦的耐药性：β-内酰胺酶蛋白质工程产生独特的抗生素耐药表型。
mBio. 2017 Oct 31;8(5):e00528-17. doi: 10.1128/mBio.00528-17.
4
KPC-mediated resistance in Klebsiella pneumoniae in two hospitals in Padua, Italy, June 2009-December 2011: massive spreading of a KPC-3-encoding plasmid and involvement of non-intensive care units.2009 年 6 月至 2011 年 12 月意大利帕多瓦两所医院中的肺炎克雷伯菌中产 KPC 酶耐药：一种携带 KPC-3 基因的质粒的广泛传播及非重症监护病房的参与
Gut Pathog. 2012 Jul 16;4(1):7. doi: 10.1186/1757-4749-4-7.
5
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.产肺炎克雷伯菌碳青霉烯酶细菌的真正威胁。
Lancet Infect Dis. 2009 Apr;9(4):228-36. doi: 10.1016/S1473-3099(09)70054-4.
6
A structural, epidemiological & genetic overview of carbapenemases (KPCs).碳青霉烯酶（KPCs）的结构、流行病学及遗传学概述
Indian J Med Res. 2016 Jul;144(1):21-31. doi: 10.4103/0971-5916.193279.
7
The Epidemiology, Evolution, and Treatment of KPC-Producing Organisms.产KPC（肺炎克雷伯菌碳青霉烯酶）微生物的流行病学、进化及治疗
Curr Infect Dis Rep. 2018 May 5;20(6):13. doi: 10.1007/s11908-018-0617-x.
8
Molecular epidemiology of carbapenem resistant Enterobacteriaceae in Valle d'Aosta region, Italy, shows the emergence of KPC-2 producing Klebsiella pneumoniae clonal complex 101 (ST101 and ST1789).意大利瓦莱达奥斯塔地区耐碳青霉烯类肠杆菌科的分子流行病学研究显示，产 KPC-2 的肺炎克雷伯菌克隆复合体 101（ST101 和 ST1789）的出现。
BMC Microbiol. 2015 Nov 9;15(1):260. doi: 10.1186/s12866-015-0597-z.
9
Phenotypic and molecular detection of the bla gene in clinical isolates from inpatients at hospitals in São Luis, MA, Brazil.巴西马塞约州圣路易斯市医院住院患者临床分离株中bla基因的表型和分子检测
BMC Infect Dis. 2016 Dec 7;16(1):737. doi: 10.1186/s12879-016-2072-3.
10
[KPC carbapenemases: what is at stake in clinical microbiology?].[KPC碳青霉烯酶：临床微生物学面临的风险是什么？]
Pathol Biol (Paris). 2010 Feb;58(1):39-45. doi: 10.1016/j.patbio.2009.07.026. Epub 2009 Oct 24.
引用本文的文献
1
Evidence of hypervirulent carbapenem-resistant Klebsiella pneumoniae in cats with urinary affections and associated humans in Egypt.埃及患有泌尿系统疾病的猫及其相关人类中出现高毒力耐碳青霉烯肺炎克雷伯菌的证据。
Sci Rep. 2025 Apr 15;15(1):12950. doi: 10.1038/s41598-025-96147-8.
2
Use of MALDI-TOF VITEK MS for rapid and efficient identification of KPC-type carbapenemases in Enterobacterales carrying the Tn4401a transposon.使用基质辅助激光解吸电离飞行时间质谱仪（MALDI-TOF VITEK MS）快速高效鉴定携带Tn4401a转座子的肠杆菌科细菌中的KPC型碳青霉烯酶。
Eur J Clin Microbiol Infect Dis. 2025 Jun;44(6):1443-1453. doi: 10.1007/s10096-025-05097-6. Epub 2025 Apr 3.
3
Bacteriophage treatment is effective against carbapenem-resistant (KPC) in a neutropenic murine model of gastrointestinal translocation and renal infection.在中性粒细胞减少的胃肠道易位和肾脏感染小鼠模型中，噬菌体治疗对耐碳青霉烯类（KPC）有效。
Antimicrob Agents Chemother. 2025 Feb 13;69(2):e0091924. doi: 10.1128/aac.00919-24. Epub 2024 Dec 20.
4
Gas Chromatography-Ion Mobility Spectrometry Reveals Acetoin as a Biomarker for Carbapenemase-Producing Klebsiella pneumoniae.气相色谱-离子淌度谱法揭示乙酰-3-羟丁酮是产碳青霉烯酶肺炎克雷伯菌的生物标志物。
Med Sci Monit. 2024 Jul 31;30:e944507. doi: 10.12659/MSM.944507.
5
16S rRNA amplicon sequencing and antimicrobial resistance profile of intensive care units environment in 41 Brazilian hospitals.41 家巴西医院重症监护病房环境的 16S rRNA 扩增子测序和抗菌药物耐药谱。
Front Public Health. 2024 Jul 15;12:1378413. doi: 10.3389/fpubh.2024.1378413. eCollection 2024.
6
Carbapenemase Producing (KPC): What Is the Best MALDI-TOF MS Detection Method.产碳青霉烯酶（KPC）：最佳基质辅助激光解吸电离飞行时间质谱检测方法是什么。
Antibiotics (Basel). 2021 Dec 17;10(12):1549. doi: 10.3390/antibiotics10121549.
7
Surgical Antibiotic Prophylaxis in an Era of Antibiotic Resistance: Common Resistant Bacteria and Wider Considerations for Practice.抗生素耐药时代的外科手术抗生素预防：常见耐药细菌及实践中的更广泛考量
Infect Drug Resist. 2021 Dec 7;14:5235-5252. doi: 10.2147/IDR.S319780. eCollection 2021.
8
Co-Existence of Certain ESBLs, MBLs and Plasmid Mediated Quinolone Resistance Genes among MDR Isolated from Different Clinical Specimens in Egypt.埃及不同临床标本中分离出的多重耐药菌中某些超广谱β-内酰胺酶、金属β-内酰胺酶和质粒介导喹诺酮耐药基因的共存情况
Antibiotics (Basel). 2021 Jul 9;10(7):835. doi: 10.3390/antibiotics10070835.
9
Detection of several carbapenems resistant and virulence genes in classical and hyper-virulent strains of Klebsiella pneumoniae isolated from hospitalized neonates and adults in Khartoum.从喀土穆住院新生儿和成人中分离的经典和超毒力肺炎克雷伯菌中检测到几种碳青霉烯类耐药和毒力基因。
BMC Res Notes. 2020 Jul 1;13(1):312. doi: 10.1186/s13104-020-05157-4.
10
Defining the oral microbiome by whole-genome sequencing and resistome analysis: the complexity of the healthy picture.通过全基因组测序和抗药基因组分析定义口腔微生物组：健康状况的复杂性。
BMC Microbiol. 2020 May 18;20(1):120. doi: 10.1186/s12866-020-01801-y.
本文引用的文献
1
Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy.产碳青霉烯酶肺炎克雷伯菌血流感染患者的死亡率预测因素：联合治疗的重要性。
Clin Infect Dis. 2012 Oct;55(7):943-50. doi: 10.1093/cid/cis588. Epub 2012 Jul 2.
2
In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli.多药耐药肺炎克雷伯菌和大肠埃希菌体内出现替加环素耐药。
Antimicrob Agents Chemother. 2012 Aug;56(8):4516-8. doi: 10.1128/AAC.00234-12. Epub 2012 May 29.
3
Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe.肠杆菌科中产碳青霉烯酶的快速进化和传播在欧洲。
Clin Microbiol Infect. 2012 May;18(5):413-31. doi: 10.1111/j.1469-0691.2012.03821.x.
4
5
Detection of an international multiresistant clone belonging to sequence type 654 involved in the dissemination of KPC-producing Pseudomonas aeruginosa in Argentina.在阿根廷检测到属于序列型654的国际多重耐药克隆，该克隆参与了产KPC的铜绿假单胞菌的传播。
J Antimicrob Chemother. 2012 May;67(5):1291-3. doi: 10.1093/jac/dks032. Epub 2012 Feb 20.
6
Emergence of Proteus mirabilis harboring blaKPC-2 and qnrD in a Chinese Hospital.中国某医院出现产碳青霉烯酶肺炎克雷伯菌（携带 blaKPC-2 和 qnrD）。
Antimicrob Agents Chemother. 2012 May;56(5):2278-82. doi: 10.1128/AAC.05519-11. Epub 2012 Feb 21.
7
Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens.产 KPC 肺炎克雷伯菌血症的治疗转归：联合抗菌方案的优势。
Antimicrob Agents Chemother. 2012 Apr;56(4):2108-13. doi: 10.1128/AAC.06268-11. Epub 2012 Jan 17.
8
blaKPC and rmtB on a single plasmid in Enterobacter amnigenus and Klebsiella pneumoniae isolates from the same patient.blaKPC 和 rmtB 位于来自同一患者的肠杆菌属和肺炎克雷伯菌分离株的单个质粒上。
Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1585-91. doi: 10.1007/s10096-011-1481-x. Epub 2012 Jan 12.
9
Detection of Citrobacter koseri carrying beta-lactamase KPC-2 in a hospitalised patient, Greece, July 2011.2011 年 7 月，希腊一名住院患者携带产 KPC-2 型β-内酰胺酶的科氏柠檬酸杆菌的检测。
Euro Surveill. 2011 Oct 13;16(41):19990.
10
Importation of KPC-2-producing Escherichia coli from India.从印度输入产KPC-2的大肠杆菌。
J Antimicrob Chemother. 2012 Jan;67(1):242-3. doi: 10.1093/jac/dkr426. Epub 2011 Oct 3.
Zotero 插件