Masoud Salwa Mahmoud, Abd El-Baky Rehab Mahmoud, Aly Sherine A, Ibrahem Reham Ali
Department of Microbiology and Immunology, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Department of Microbiology and Immunology, Faculty of Pharmacy, Deraya University, Minia 11566, Egypt.
Antibiotics (Basel). 2021 Jul 9;10(7):835. doi: 10.3390/antibiotics10070835.
The emergence of multi-drug resistant (MDR) strains and even pan drug resistant (PDR) strains is alarming. In this study, we studied the resistance pattern of pathogens recovered from patients with different infections in different hospitals in Minia, Egypt and the co-existence of different resistance determinants. was the most prevalent among patients suffering from urinary tract infections (62%), while they were the least isolated from eye infections (10%). High prevalence of MDR isolates was found (73%) associated with high ESBLs and MBLs production (89.4% and 64.8%, respectively). (80%) and (43%) were the most frequent ESBL and MBL, respectively. None of the isolates harbored and carbapenemase like genes. Also, the fluoroquinolone modifying enzyme gene was detected in 25.2% of the isolates. More than one gene was found in 81% of the isolates. Azithromycin was one of the most effective antibiotics against MDR pathogens. The high MAR index of the isolates and the high prevalence of resistance genes, indicates an important public health concern and high-risk communities where antibiotics are abused.
多重耐药（MDR）菌株甚至泛耐药（PDR）菌株的出现令人担忧。在本研究中，我们研究了从埃及米尼亚不同医院的不同感染患者中分离出的病原体的耐药模式以及不同耐药决定因素的共存情况。在患有尿路感染的患者中最为常见（62%），而从眼部感染中分离出的比例最低（10%）。发现多重耐药菌株的高流行率（73%）与超广谱β-内酰胺酶（ESBLs）和金属β-内酰胺酶（MBLs）的高产生率相关（分别为89.4%和64.8%）。ESBL和MBL最常见的分别是（80%）和（43%）。没有分离株携带和碳青霉烯酶样基因。此外，在25.2%的分离株中检测到氟喹诺酮修饰酶基因。81%的分离株中发现了不止一个基因。阿奇霉素是对抗多重耐药病原体最有效的抗生素之一。分离株的高多重耐药指数和耐药基因的高流行率表明存在重要的公共卫生问题以及抗生素滥用的高风险社区。
