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本文引用的文献

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The other allele: exploring the long allele of the serotonin transporter gene as a potential risk factor for psychopathy: a review of the parallels in findings.另一个等位基因：探索血清素转运体基因的长等位基因作为精神病态的潜在风险因素：研究结果相似性的综述。
Neurosci Biobehav Rev. 2011 Jan;35(3):612-20. doi: 10.1016/j.neubiorev.2010.07.005. Epub 2010 Jul 30.
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The status of diabetes care in Mexican population: are we making a difference? Results of the National Health and Nutrition Survey 2006.墨西哥人口的糖尿病护理状况：我们是否有所作为？2006 年全国健康和营养调查结果。
Salud Publica Mex. 2010;52 Suppl 1:S36-43. doi: 10.1590/s0036-36342010000700007.
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The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms.5-羟色胺转运体基因多态性（5-HTTLPR）：等位基因变异与抑郁症状的关联。
Depress Anxiety. 2010 Mar;27(3):260-9. doi: 10.1002/da.20660.
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The serotonin transporter promoter polymorphism (5-HTTLPR) is associated with type 2 diabetes.5-羟色胺转运体启动子多态性（5-HTTLPR）与 2 型糖尿病有关。
Clin Chim Acta. 2010 Feb;411(3-4):167-71. doi: 10.1016/j.cca.2009.10.022. Epub 2009 Nov 2.
5
Interactions between genotype and depressive symptoms on obesity.肥胖中基因型与抑郁症状之间的相互作用。
Behav Genet. 2009 May;39(3):296-305. doi: 10.1007/s10519-009-9266-z. Epub 2009 Apr 1.
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Type 2 diabetes: new genes, new understanding.2型糖尿病：新基因，新认识。
Trends Genet. 2008 Dec;24(12):613-21. doi: 10.1016/j.tig.2008.09.004. Epub 2008 Oct 25.
7
Clinical depressive symptoms and diabetes in a binational border population.双边边境人群中的临床抑郁症状与糖尿病
J Am Board Fam Med. 2008 May-Jun;21(3):223-33. doi: 10.3122/jabfm.2008.03.070255.
8
Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adults.SLC6A4基因功能性5-HTTLPR变体对成年男性肥胖风险的影响。
Obesity (Silver Spring). 2008 Feb;16(2):488-91. doi: 10.1038/oby.2007.64.
9
Genes implicated in serotonergic and dopaminergic functioning predict BMI categories.与血清素能和多巴胺能功能相关的基因可预测体重指数类别。
Obesity (Silver Spring). 2008 Feb;16(2):348-55. doi: 10.1038/oby.2007.65.
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PLINK: a tool set for whole-genome association and population-based linkage analyses.PLINK：一个用于全基因组关联分析和基于群体的连锁分析的工具集。
Am J Hum Genet. 2007 Sep;81(3):559-75. doi: 10.1086/519795. Epub 2007 Jul 25.

血清素转运体基因（SLC6A4）5-HTTLPR 多态性与墨西哥人体质量指数类别相关，但与 2 型糖尿病无关。

Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans.

机构信息

Facultad de Medicina e Ingeniería en Sistemas Computacionales, Departamento de Genética Aplicada a la Medicina, Universidad Autónoma de Tamaulipas, H. Matamoros Tamaulipas, México.

出版信息

Genet Mol Biol. 2012 Jul;35(3):589-93. doi: 10.1590/S1415-47572012005000048. Epub 2012 Jul 26.

DOI:10.1590/S1415-47572012005000048
PMID:23055796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3459407/
Abstract

The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy-Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).

摘要

血清素能系统被假设与 2 型糖尿病（T2DM）和体重指数（BMI）类别中的生物易感性有关。我们通过分析来自墨西哥普通人群的 138 名被诊断患有 T2DM 的个体和 172 名无关对照者的样本，研究了 5-HTTLPR 多态性（启动子区域的 L 和 S 等位基因）在血清素转运蛋白基因（SLC6A4）中与 T2DM 和/或更高 BMI 发展的可能相关性。在总样本中，基因型符合哈迪-温伯格平衡，S 等位基因频率为 0.58。在这个墨西哥人群样本中，5-HTTLPR 多态性与 T2DM 的发展之间没有统计学关联（p = 0.12）。然而，在调整年龄、性别和 T2DM 后，对 L 等位基因和增加的 BMI 的逻辑回归分析显示出相关性（p = 0.02，OR 1.74，95%CI：1.079-2.808）。