血清素转运体基因（SLC6A4）5-HTTLPR 多态性与墨西哥人体质量指数类别相关，但与 2 型糖尿病无关。
Association of a serotonin transporter gene (SLC6A4) 5-HTTLPR polymorphism with body mass index categories but not type 2 diabetes mellitus in Mexicans.
机构信息
Facultad de Medicina e Ingeniería en Sistemas Computacionales, Departamento de Genética Aplicada a la Medicina, Universidad Autónoma de Tamaulipas, H. Matamoros Tamaulipas, México.
出版信息
Genet Mol Biol. 2012 Jul;35(3):589-93. doi: 10.1590/S1415-47572012005000048. Epub 2012 Jul 26.
The serotonergic system has been hypothesized to contribute to the biological susceptibility to type 2 diabetes mellitus (T2DM) and body-mass index (BMI) categories. We investigate a possible association of 5-HTTLPR polymorphism (L and S alleles) in the promoter region of the serotonin transporter gene (SLC6A4) with the development of T2DM and/or higher BMI by analyzing a sample of 138 individuals diagnosed with T2DM and 172 unrelated controls from the Mexican general population. In the total sample genotypes were distributed according to Hardy-Weinberg equilibrium, and S allele frequency was 0.58. There was no statistical association between 5-HTTLPR polymorphism and the development of T2DM in this Mexican population sample (p = 0.12). Nevertheless, logistic regression analysis of the L allele and increased BMI disclosed an association, after adjusting for age, sex and T2DM (p = 0.02, OR 1.74, 95% CI: 1.079-2.808).
血清素能系统被假设与 2 型糖尿病（T2DM）和体重指数（BMI）类别中的生物易感性有关。我们通过分析来自墨西哥普通人群的 138 名被诊断患有 T2DM 的个体和 172 名无关对照者的样本，研究了 5-HTTLPR 多态性（启动子区域的 L 和 S 等位基因）在血清素转运蛋白基因（SLC6A4）中与 T2DM 和/或更高 BMI 发展的可能相关性。在总样本中，基因型符合哈迪-温伯格平衡，S 等位基因频率为 0.58。在这个墨西哥人群样本中，5-HTTLPR 多态性与 T2DM 的发展之间没有统计学关联（p = 0.12）。然而，在调整年龄、性别和 T2DM 后，对 L 等位基因和增加的 BMI 的逻辑回归分析显示出相关性（p = 0.02，OR 1.74，95%CI：1.079-2.808）。
Zotero 插件