伏立康唑成功治疗慢性肉芽肿病患者的真菌性骨髓炎。
Successful treatment of fungal osteomyelitis with voriconazole in a patient with chronic granulomatous disease.
作者信息
Mohammadpour Masoud, Mamishi Setareh, Oaji Mahsa, Pourpak Zahra, Parvaneh Nima
机构信息
Department of Pediatrics, Tehran University of Medical Sciences, Tehran, IR Iran ; Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, IR Iran.
出版信息
Iran J Pediatr. 2010 Dec;20(4):487-90.
BACKGROUND
Chronic granulomatous disease (CGD) is an immunodeficiency affecting phagocytic leukocytes. Defective respiratory burst mechanism renders the affected patients to be susceptible to catalase positive microorganisms. With the great successes in antibacterial prophylaxis and therapy, fungal infections are a persistent problem. Invasive aspergillosis is the most important cause of mortality in CGD.
CASE PRESENTATION
We describe a nine year-old boy with CGD who presented with aspergillus induced skull osteomyelitis. He was successfully treated with voriconazole after initial failure of amphotericin B therapy.
CONCLUSION
Currently, newer triazoles are recommended as initial therapy for invasive aspergillosis in immunodeficiency states such as CGD.
背景
慢性肉芽肿病（CGD）是一种影响吞噬性白细胞的免疫缺陷病。呼吸爆发机制缺陷使患病患者易受过氧化氢酶阳性微生物感染。尽管在抗菌预防和治疗方面取得了巨大成功，但真菌感染仍是一个持续存在的问题。侵袭性曲霉病是CGD患者死亡的最重要原因。
病例报告
我们描述了一名患有CGD的9岁男孩，他因曲霉感染导致颅骨骨髓炎。在两性霉素B治疗初期失败后，他接受伏立康唑治疗并获得成功。
结论
目前，新型三唑类药物被推荐作为CGD等免疫缺陷状态下侵袭性曲霉病的初始治疗药物。
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