Chi Haiyan, Zhou Yuping, Li Li
Department of Endocrinology, Weihai Municipal Hospital, Weihai 264200, China.
Wei Sheng Yan Jiu. 2012 Jul;41(4):540-2.
To investigate the effect of selenium on the TGAb, TMAb, FT3, FT4 and TSH level of rats with excessive intake of iodine.
Wistar rats were divided into three groups by random:normal control, high iodine group and high iodine plus selenium group. Rats in the high iodine plus selenium group were lavaged with sodium selenite for 10 weeks. The levels of serum TGAb, TMAb, FT3, FT4 and TSH were tested at different time of the experiment.
There were no significant change on levels of FT3, FT4 and TSH (P > 0.05). The levels of TGAb and TMAb in the high iodine group were increased slowly (P < 0.05), but no significant change was observed in the high iodine plus selenium group.
Excessive intake of iodine might induce goiter, and selenium might have antagonistic effect on it.
探讨硒对碘过量摄入大鼠甲状腺球蛋白抗体（TGAb）、甲状腺微粒体抗体（TMAb）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）及促甲状腺激素（TSH）水平的影响。
将Wistar大鼠随机分为三组：正常对照组、高碘组和高碘加硒组。高碘加硒组大鼠用亚硒酸钠灌胃10周。在实验的不同时间检测血清TGAb、TMAb、FT3、FT4和TSH水平。
FT3、FT4和TSH水平无显著变化（P>0.05）。高碘组TGAb和TMAb水平缓慢升高（P<0.05），但高碘加硒组未见显著变化。
碘过量摄入可能诱发甲状腺肿，硒可能对其有拮抗作用。
