Sáez-Llorens X, Mustafa M M, Ramilo O, Fink C, Beutler B, Nelson J D
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas.
Am J Dis Child. 1990 Mar;144(3):353-6. doi: 10.1001/archpedi.1990.02150270103035.
Tumor necrosis factor alpha and interleukin 1 beta concentrations were measured in synovial fluid of 24 infants and children with diagnoses of suppurative arthritis (n = 16) and other kinds of arthritis (n = 8). Large concentrations of tumor necrosis factor alpha (range, 100 to 85,000 pg/mL) were found in 12 (75%) of 16 patients with bacterial infection and in none of the patients with noninfectious origins. Large concentrations of interleukin 1 beta (greater than 200 pg/mL) were found in 15 (94%) of 16 patients with bacterial infection and in none of the other patients. In the latter group, small concentrations of interleukin 1 (range, 40 to 120 pg/mL) were present in 5 (63%) of 8 patients. Serum samples obtained simultaneously were negative for both cytokines. Tumor necrosis factor alpha and interleukin 1 beta concentrations correlated significantly and with leukocyte counts in synovial fluid. We conclude that large concentrations of tumor necrosis factor alpha and interleukin 1 beta are produced locally in patients with suppurative arthritis and they may be potentially useful in differentiating this condition from other kinds of arthritis.
在24名诊断为化脓性关节炎（n = 16）和其他类型关节炎（n = 8）的婴幼儿和儿童的滑液中测量了肿瘤坏死因子α和白细胞介素1β的浓度。在16例细菌感染患者中的12例（75%）发现了高浓度的肿瘤坏死因子α（范围为100至85,000 pg/mL），而在非感染性病因的患者中均未发现。在16例细菌感染患者中的15例（94%）发现了高浓度的白细胞介素1β（大于200 pg/mL），而其他患者中均未发现。在后一组中，8例患者中的5例（63%）存在低浓度的白细胞介素1（范围为40至120 pg/mL）。同时采集的血清样本中两种细胞因子均为阴性。肿瘤坏死因子α和白细胞介素1β的浓度与滑液中的白细胞计数显著相关。我们得出结论，化脓性关节炎患者局部产生高浓度的肿瘤坏死因子α和白细胞介素1β，它们可能有助于将这种疾病与其他类型的关节炎区分开来。
