Westacott C I, Whicher J T, Barnes I C, Thompson D, Swan A J, Dieppe P A
Rheumatology Unit, University of Bristol, UK.
Ann Rheum Dis. 1990 Sep;49(9):676-81. doi: 10.1136/ard.49.9.676.
Interleukin-1 beta, interleukin-2, tumour necrosis factor alpha, and the interferons, alfa and gamma, were measured concurrently in synovial fluid samples from 68 patients with rheumatic diseases. Mean interleukin-1 beta concentrations (130.3 (SD 22) pg/ml) were higher in synovial fluids from patients with rheumatoid arthritis (RA) than in those from patients with osteoarthritis (27.8(4.5)pg/ml), while measurements in synovial fluids from patients with seronegative spondarthritis were intermediate (72.7 (32) pg/ml). Interleukin-2 and tumour necrosis factor alpha concentrations were lower in the inflammatory arthropathies (RA: 4.5 (0.6) U/ml, 0.39 (0.04) ng/ml; seronegative spondarthritis: 3.1 (0.3) U/ml, 0.33 (0.03) ng/ml respectively) than those in patients with osteoarthritis (5.2 (0.6) U/ml; 0.05 (0.04) ng/ml). Interleukin-2 and tumour necrosis factor alpha concentrations correlated in all groups (r = 0.7), as did the interferons alfa and gamma (r = 0.7). There was no relation between interleukin-1 beta and either interleukin-2 or tumour necrosis factor alpha, or between the interferons and any other cytokine. Several distinct cytokine patterns were noted. Synovial fluids from two non-arthritic subjects were also examined: interleukin-1 beta concentrations were low, but concentrations of the other cytokines were higher than those seen in most arthritic fluids.
同时检测了68例风湿性疾病患者滑液样本中的白细胞介素-1β、白细胞介素-2、肿瘤坏死因子α以及α和γ干扰素。类风湿关节炎（RA）患者滑液中的平均白细胞介素-1β浓度（130.3（标准差22）pg/ml）高于骨关节炎患者（27.8（4.5）pg/ml），而血清阴性脊柱关节炎患者滑液中的测量值介于两者之间（72.7（32）pg/ml）。炎症性关节病患者（RA：4.5（0.6）U/ml，0.39（0.04）ng/ml；血清阴性脊柱关节炎：分别为3.1（0.3）U/ml，0.33（0.03）ng/ml）的白细胞介素-2和肿瘤坏死因子α浓度低于骨关节炎患者（5.2（0.6）U/ml；0.05（0.04）ng/ml）。所有组中白细胞介素-2和肿瘤坏死因子α浓度均呈相关性（r = 0.7），α和γ干扰素也呈相关性（r = 0.7）。白细胞介素-1β与白细胞介素-2或肿瘤坏死因子α之间，以及干扰素与任何其他细胞因子之间均无关联。观察到几种不同的细胞因子模式。还检测了两名非关节炎受试者的滑液：白细胞介素-1β浓度较低，但其他细胞因子的浓度高于大多数关节炎滑液中的浓度。
