Department of Biochemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey.
J Food Sci. 2012 Nov;77(11):H224-30. doi: 10.1111/j.1750-3841.2012.02920.x. Epub 2012 Oct 11.
Gastroprotective effects of α-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.
已经研究了α-硫辛酸 (ALA) 对消炎痛 (IND) 诱导的氧化性胃损伤的胃保护作用。ALA 的所有剂量（50、75、100、150、200 和 300mg/kg 体重）均将溃疡指数降低了 88.2%至 96.1%。在胃组织的生化分析中，ALA 给药降低了胃组织中脂质过氧化 (LPO) 的水平和髓过氧化物酶 (MPO) 和过氧化氢酶 (CAT) 的活性，IND 应用后这些物质的活性增加。ALA 还增加了谷胱甘肽 (GSH) 的水平以及超氧化物歧化酶 (SOD) 和谷胱甘肽 S-转移酶 (GST) 的活性，这些物质在胃损伤的胃组织中减少。总之，ALA 的胃保护作用可能归因于其对抗氧化防御系统的改善作用。
