National Research Institute of Chinese Medicine, Taipei, Taiwan.
Planta Med. 2012 Nov;78(17):1873-7. doi: 10.1055/s-0032-1327785. Epub 2012 Oct 11.
Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.
2-去甲基氧化黄连碱（1）和 5-乙氧羰基辛可宁碱（2），以及三十四个已知化合物。对分离得到的化合物进行了 MCF-7、H460、HT-29 和 CEM 人癌细胞系的细胞毒性测试。结果表明，在对目标癌细胞系的细胞毒性活性方面，蝙蝠葛任碱（16）、6-O-去甲荷叶碱（17）、蝙蝠葛苏林碱（18）、荷叶碱（19）和 6-O-去甲蝙蝠葛任碱（20）显示出了差异作用。同时，16 和 19 还表现出了显著的血管生成抑制作用。
