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关于安非他命在治疗成瘾方面的作用机制的假设。

Hypotheses regarding the mechanisms of ayahuasca in the treatment of addictions.

出版信息

J Psychoactive Drugs. 2012 Jul-Aug;44(3):200-8. doi: 10.1080/02791072.2012.704590.

DOI:10.1080/02791072.2012.704590
PMID:23061319
Abstract

Ayahuasca is a medicinal plant mixture utilized by indigenous peoples throughout the Amazon River basin for healing purposes. The "vine of the soul" or "vine of death," as it is known in South America, contains a combination of monoamine oxidase inhibitors and N,N-dimethyltryptamine (DMT). When ingested together, these medicines produce profound alterations in consciousness. Increasingly, ayahuasca is being utilized to treat addictions. However, the mechanism of action by which ayahuasca treats addictions remains unclear. We offer four hypotheses to explain possible biochemical, physiological, psychological, and transcendent mechanisms by which ayahuasca may exert its anti-addiction effects.

摘要

安非他命是一种药用植物混合物,被亚马逊河流域的土著人民用于治疗目的。这种“灵魂之藤”或“死亡之藤”,正如南美洲所知道的那样,含有单胺氧化酶抑制剂和 N,N-二甲基色胺(DMT)的组合。当一起摄入时,这些药物会导致意识的深刻改变。安非他命越来越多地被用于治疗成瘾。然而,安非他命治疗成瘾的作用机制尚不清楚。我们提出了四个假设来解释安非他命可能发挥其抗成瘾作用的可能的生化、生理、心理和超越的机制。

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PCN Rep. 2023 Oct 2;2(4):e146. doi: 10.1002/pcn5.146. eCollection 2023 Dec.
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Psychedelic unselfing: self-transcendence and change of values in psychedelic experiences.
迷幻的自我消解:迷幻体验中的自我超越与价值观转变
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