University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chhattisgarh, 492010, India.
J Control Release. 2012 Nov 28;164(1):26-40. doi: 10.1016/j.jconrel.2012.09.017. Epub 2012 Oct 10.
Transdermal drug delivery system (TDDS) utilizes the skin as executable route for drug administration but the foremost barrier against drug permeability is the stratum corneum and therefore, it limits therapeutic bioavailability of the bioactive. This review focuses on the recent advancements in the TDDS which include iontophoresis, sonophoresis, electroporation, microneedles, magnetophoresis, photomechanical waves and electron beam irradiation. These advancements are exhaustively discussed with techniques involved with their beneficial claims for different categories of bioactive. However, a lot of research has been carried out in TDDS, still the system has many pros and cons such as inconsistent drug release, prevention of burst release formulation and problems related to toxicity. In addition to that, to exploit the TDDS more efficiently scientists have worked on some combinational approaches for manufacturing TDDS viz., chemical-iontophoresis, chemical-electroporation, chemical-ultrasound, iontophoresis-ultrasound, electroporation-iontophoresis electroporation-ultrasound and pressure waves-chemicals and reported the synergistic effect of the same for safe, effective and practical use of TDDS. The present article covers all the above-mentioned aspects in detail and hence the article will assuredly serve as an enlightening tool for the visionaries working in the concerned area.
透皮给药系统（TDDS）利用皮肤作为药物给药的可执行途径，但药物渗透性的首要障碍是角质层，因此，它限制了生物活性物质的治疗生物利用度。本综述重点介绍了 TDDS 的最新进展，包括离子电渗、声电渗、电穿孔、微针、磁泳、光机械波和电子束辐射。这些进展与涉及不同类别生物活性物质的有益主张的技术进行了详细讨论。然而，尽管在 TDDS 方面进行了大量研究，但该系统仍存在许多优缺点，例如药物释放不一致、防止突释制剂以及与毒性相关的问题。此外，为了更有效地利用 TDDS，科学家们在制造 TDDS 方面开展了一些组合方法的研究，例如化学离子电渗、化学电穿孔、化学超声、离子电渗超声、电穿孔离子电渗超声和压力波化学，并报告了相同方法的协同效应，以实现 TDDS 的安全、有效和实际应用。本文详细涵盖了上述所有方面，因此，该文将无疑成为从事相关领域工作的有识之士的启发工具。
