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智能透皮纳米颗粒作为用于精准治疗的协同先进递送系统。

Intelligent transdermal nanoparticles as synergizing advanced delivery systems for precision therapeutics.

作者信息

Guo Zhouying, Zhang Yi'nan, Zhao Man, Zhang Wenyuan, Li Xiaofang, Zhou Fang, Peng Haisheng, Wang Qun, Chen Zhiwei

机构信息

Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Zhejiang Chinese Medical University, 75 Jinxiu Road, Wenzhou, 325000, China.

The First School of Clinical Medicine of Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310051, China.

出版信息

Mater Today Bio. 2025 Aug 22;34:102220. doi: 10.1016/j.mtbio.2025.102220. eCollection 2025 Oct.

DOI:10.1016/j.mtbio.2025.102220
PMID:40917520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12408414/
Abstract

Transdermal drug delivery systems (TDDS) represent a non-invasive approach to achieve controlled drug release through the skin barrier, offering stable plasma concentrations while avoiding gastrointestinal and hepatic metabolism. However, the skin barrier poses physical challenges, making it difficult for most drugs to penetrate deep tissues using TDDS. This review systematically summarizes the research progress in nanocarrier design, physical technology application, and artificial intelligence (AI)-driven TDDS optimization design aimed at overcoming the key problem of skin barrier penetration. An in-depth analysis of nanocarriers, such as soft vesicles, nanoemulsions, rigid nanoparticles, and physically assisted enhancement technologies, and AI-driven research on skin penetration enhancement in TDDS was summarized. An integrated technical framework demonstrates how microneedle arrays, iontophoresis, electroporation, and photoporation synergize with nanoparticles to achieve spatiotemporally controlled transdermal drug delivery. Additionally, the review emphasizes the clinical application potential of these integrated technologies and offers a comprehensive, multidimensional perspective to advance innovation in TDDS.

摘要

经皮给药系统（TDDS）是一种通过皮肤屏障实现药物控释的非侵入性方法，可提供稳定的血浆浓度，同时避免胃肠道和肝脏代谢。然而，皮肤屏障带来了物理挑战，使得大多数药物难以通过TDDS穿透深层组织。本综述系统地总结了纳米载体设计、物理技术应用以及人工智能（AI）驱动的TDDS优化设计方面的研究进展，旨在克服皮肤屏障穿透这一关键问题。总结了对纳米载体（如软囊泡、纳米乳液、刚性纳米颗粒）和物理辅助增强技术的深入分析，以及AI驱动的TDDS皮肤渗透增强研究。一个综合技术框架展示了微针阵列、离子电渗、电穿孔和光穿孔如何与纳米颗粒协同作用，以实现时空可控的经皮给药。此外，该综述强调了这些综合技术的临床应用潜力，并提供了一个全面、多维度的视角来推动TDDS的创新。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/418366d3e50d/gr12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/d0c9dc5def45/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/518ba7062787/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/cd74807be760/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/c3921ffb593e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/69a8613a4a4d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/43b6460d21b3/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/0fd34cf92f28/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/be2c8a7303fc/gr10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11dc/12408414/418366d3e50d/gr12.jpg

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