玻璃体内注射贝伐单抗治疗弹性假黄瘤中血管样条纹所致脉络膜新生血管后发生急性卒中：一种非适应证治疗后的严重全身性不良事件。
Acute stroke after intravitreal bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum : a severe systemic adverse event after an off-label procedure.
作者信息
Besozzi Gianluca, Ferrara Andrea, Epifani Enrico, Intini Daniela, Apruzzese Margherita, Provenzano Antonio, Vetrugno Michele
机构信息
Anthea Hospital, GVM Care and Research, Via Camillo Rosalba, 35, 70125, Bari, Italy.
出版信息
Int Ophthalmol. 2013 Apr;33(2):181-3. doi: 10.1007/s10792-012-9647-9. Epub 2012 Oct 14.
To report the occurrence of acute stroke after intravitreal bevacizumab administration to treat choroidal neovascularization due to angioid streaks in a patient affected by pseudoxanthoma elasticum. A 54-year-old man with pseudoxanthoma elasticum had vision loss because of choroidal neovascularization due to angioid streaks. He underwent two intravitreal bevacizumab injections. Three days after the second procedure the patient was afflicted by acute stroke. Intravitreal injection of bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum could lead to severe systemic adverse events.
报告1例患有弹性假黄瘤的患者在玻璃体内注射贝伐单抗治疗血管样条纹所致脉络膜新生血管后发生急性卒中的情况。1例54岁患有弹性假黄瘤的男性因血管样条纹所致脉络膜新生血管而视力丧失。他接受了两次玻璃体内贝伐单抗注射。第二次注射后三天，该患者发生急性卒中。玻璃体内注射贝伐单抗治疗弹性假黄瘤中血管样条纹所致脉络膜新生血管可能导致严重的全身性不良事件。
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