Division of Epidemiology and Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, MCN B-2104, Nashville, TN 37232-2400, USA.
Cancer Causes Control. 2012 Dec;23(12):1965-75. doi: 10.1007/s10552-012-0074-z. Epub 2012 Oct 12.
B vitamins and methionine have been postulated to have potential effects on carcinogenesis; however, findings from previous epidemiologic studies on B vitamins, methionine, and lung cancer risk are inconsistent. We investigated associations of dietary intakes of B vitamins (i.e., riboflavin, niacin, vitamin B6, folate, and vitamin B12) and methionine with lung cancer risk among female never smokers.
The Shanghai Women's Health Study, a population-based, prospective cohort study, included 74,941 women. During a median follow-up of 11.2 years, 428 incident lung cancer cases accrued among 71,267 women with no history of smoking or cancer at baseline. Baseline dietary intakes were derived from a validated, interviewer-administered food frequency questionnaire. Cancer incidence and vital status were ascertained through annual linkage to the Shanghai Cancer Registry and Shanghai Vital Statistics Registry databases and through biennial in-person follow-ups with participants. Adjusted hazard ratios (HR) and 95 % confidence intervals (CI) were calculated using Cox regression.
Dietary riboflavin intake was inversely associated with lung cancer risk (HR = 0.62; 95 % CI = 0.43-0.89; p trend = 0.03 for the highest quartile compared with the lowest). A higher than median intake of methionine was associated with lower risk of lung cancer (HR = 0.78; 95 % CI = 0.60-0.99); however, there was no dose-response relation. Intakes of other B vitamins were not associated with lung cancer risk.
Our study suggests that dietary riboflavin intake may be inversely associated with lung cancer risk among female never smokers, which warrants further investigation.
维生素 B 族和蛋氨酸被认为对致癌作用有潜在影响；然而，先前关于维生素 B 族、蛋氨酸与肺癌风险的流行病学研究结果并不一致。我们调查了女性不吸烟者膳食中维生素 B 族（即核黄素、烟酸、维生素 B6、叶酸和维生素 B12）和蛋氨酸的摄入量与肺癌风险之间的关系。
上海女性健康研究是一项基于人群的前瞻性队列研究，纳入了 74941 名女性。在中位随访 11.2 年期间，在 71267 名无吸烟或癌症史的基线女性中，有 428 例发生了肺癌。基线膳食摄入量来自经过验证的、由访视员管理的食物频率问卷。通过与上海癌症登记处和上海生命统计登记处数据库的年度链接以及对参与者的两年一次的随访，确定癌症发病率和生存状况。使用 Cox 回归计算调整后的风险比（HR）和 95%置信区间（CI）。
膳食核黄素摄入量与肺癌风险呈负相关（HR = 0.62；95%CI = 0.43-0.89；最高四分位与最低四分位相比，p 趋势=0.03）。高于中位数的蛋氨酸摄入量与肺癌风险降低相关（HR = 0.78；95%CI = 0.60-0.99）；然而，没有剂量反应关系。其他 B 族维生素的摄入量与肺癌风险无关。
我们的研究表明，膳食核黄素摄入量可能与女性不吸烟者的肺癌风险呈负相关，这值得进一步研究。
