Luu Hung N, Wang Renwei, Jin Aizhen, Koh Woon-Puay, Yuan Jian-Min
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Eur J Cancer Prev. 2021 May 1;30(3):275-281. doi: 10.1097/CEJ.0000000000000660.
Since previous epidemiological studies reported inconsistent associations between dietary vitamin B12 intake and lung cancer risk, more studies are warranted to clarify this association in different populations.
The association between dietary B12 intake and lung cancer risk was examined in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63 257 Singaporean Chinese men and women, 45-74 years of age at enrollment during 1993-1998 and were followed up for incidence of lung cancer for up to 25 years. Dietary vitamin B12 intake was derived from a validated food frequency questionnaire. Cox proportional hazard regression method was used to estimate hazard ratio and 95% confidence interval (CI) of lung cancer associated with dietary vitamin B12 intake with adjustment for multiple potential confounders.
After a mean follow-up of 17.64 years, 2001 study participants developed lung cancer. High levels of vitamin B12 intake were associated with significantly increased risk of lung cancer (Ptrend = 0.03). Compared with the lowest quintile, hazard ratios (95% CIs) of lung cancer for quintile 2, 3, 4, and 5 of vitamin B12 intake were 1.09 (0.95-1.25), 1.11 (0.96-1.28), 1.11 (0.97-1.29) and 1.18 (1.03-1.35), respectively. This positive association was more apparent in men than in women, in adenocarcinoma patients, or in participants with equal or less than 2 years follow-up than those with longer duration of follow-up.
Higher intake of dietary vitamin B12 was associated with increased risk of lung cancer. This highlights the potential harmful effect of vitamin B12 supplementation for lung cancer.
既往流行病学研究报道膳食维生素B12摄入量与肺癌风险之间的关联不一致，因此需要更多研究来阐明不同人群中的这种关联。
在新加坡华人健康研究中研究膳食维生素B12摄入量与肺癌风险之间的关联，这是一项正在进行的前瞻性队列研究，纳入了63257名新加坡华裔男性和女性，他们在1993 - 1998年入组时年龄为45 - 74岁，并对肺癌发病率进行了长达25年的随访。膳食维生素B12摄入量来自一份经过验证的食物频率问卷。采用Cox比例风险回归方法来估计与膳食维生素B12摄入量相关的肺癌风险比及95%置信区间（CI），并对多个潜在混杂因素进行校正。
平均随访17.64年后，2001名研究参与者患肺癌。维生素B12高摄入量与肺癌风险显著增加相关（P趋势 = 0.03）。与最低五分位数相比，维生素B12摄入量的第二、三、四和五分位数的肺癌风险比（95%CI）分别为1.09（0.95 - 1.25）、1.11（0.96 - 1.28）、1.11（0.97 - 1.29）和1.18（1.03 - 1.35）。这种正相关在男性中比在女性中、腺癌患者中或随访时间等于或少于2年的参与者中比随访时间较长的参与者中更为明显。
膳食维生素B12摄入量较高与肺癌风险增加相关。这凸显了补充维生素B12对肺癌的潜在有害影响。
