Department of Nutrition and Food Hygiene, School of Public Health, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, China.
Mol Biol Rep. 2012 Dec;39(12):10273-84. doi: 10.1007/s11033-012-1904-5. Epub 2012 Oct 14.
Epidemiological studies have evaluated the association between 3801T>C and 2455A>G polymorphisms of cytochrome P450 1A1 (CYP1A1) and prostate cancer risk. However, controversy exists regarding the role of these polymorphisms. In this work, a meta-analysis was performed to derive a more precise estimation of the relationship. PubMed and ISI Web databases were searched for all cases dated until March 2012. Crude odds ratios with 95 % confidence intervals were used to assess the strength of the association between CYP1A1 polymorphisms and prostate cancer risk. Sensitivity analysis, excluding the studies that deviated from the Hardy-Weinberg equilibrium (HWE), was performed. A total of 17 studies fulfilled our inclusion criteria in this meta-analysis, 12 of which were eligible (1,645 cases and 1,801 controls) for 3801T>C, and eleven (1,640 cases and 1,959 controls) were eligible for 2455A>G. Overall, the 2455A>G polymorphism resulted in a significantly increased susceptibility to prostate cancer. In addition, no significant associations between 3801T>C polymorphism and prostate cancer susceptibility were found in all genetic models. Only an elevated risk was observed for TC versus CC in Asian studies. However, no relationship was found in the Asian group for TC versus CC after excluding the studies that deviated from HWE. Thus, this meta-analysis finds the 2455A>G allele to be a risk factor for prostate cancer, whereas the 3801T>C status does not seem to be capable of modifying prostate cancer risk.
流行病学研究已经评估了细胞色素 P450 1A1（CYP1A1）的 3801T>C 和 2455A>G 多态性与前列腺癌风险之间的关联。然而，这些多态性的作用仍存在争议。在这项工作中，进行了荟萃分析以得出更精确的相关性估计。通过 PubMed 和 ISI Web 数据库搜索所有截至 2012 年 3 月的病例。使用粗比值比及其 95%置信区间来评估 CYP1A1 多态性与前列腺癌风险之间的关联强度。进行了敏感性分析，排除了偏离 Hardy-Weinberg 平衡（HWE）的研究。这项荟萃分析共纳入了 17 项符合条件的研究，其中 12 项（1645 例病例和 1801 例对照）符合 3801T>C，11 项（1640 例病例和 1959 例对照）符合 2455A>G。总体而言，2455A>G 多态性导致前列腺癌的易感性显著增加。此外，在所有遗传模型中，3801T>C 多态性与前列腺癌易感性之间均无显著相关性。仅在亚洲研究中观察到 TC 与 CC 相比存在升高的风险。然而，在排除偏离 HWE 的研究后，亚洲人群中未发现 TC 与 CC 之间存在相关性。因此，这项荟萃分析发现 2455A>G 等位基因是前列腺癌的危险因素，而 3801T>C 状态似乎不能改变前列腺癌的风险。
