Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK.
BMJ Open. 2012 Oct 11;2(5). doi: 10.1136/bmjopen-2012-001485. Print 2012.
Although the prevalence of asthma and atopy has been noted to have increased in recent decades, patterns of asthma prevalence have, traditionally, been difficult to track. Most reports on trends in childhood asthma have been cross-sectional measuring the prevalence in cohorts of similar aged children at different time points. The aim of this paper is to report on the prevalence of symptoms in the same cohort at two separate time points.
Retrospective cohort study.
Community-based study, Central Manchester.
MANCAS1, study n=5086, participation n=2414. MANCAS2, study n=6338, participation n=1608. Children born in a hospital in Manchester within specified dates and still living or attending a school in Central Manchester were eligible for inclusion. Children on an 'at-risk' register or living with short-term carers were excluded.
Data on respiratory symptoms were collected at two separate time points using parent completed questionnaires.
Response rate for MANCAS1 was 47.5% and 25.4% for MANCAS2. There were 801 individuals for whom a response to both studies was received. There was a significant reduction in the prevalence of night cough (29.5% vs 18.3%, McNemar <0.01) and antibiotic use for respiratory infections (9.1% vs 4.3%, McNemar <0.01) between the two study time points. The prevalence of hay fever/eczema increased (41.6% vs 46.9%, McNemar <0.01) between the two studies. There was no significant difference in the prevalence of wheeze, exercise-induced wheeze or asthma medication.
Although this report of respiratory symptom prevalence in the same population at two time points over a 7-year period shows a constant burden of asthma symptoms, there is some suggestion of variability in asthma symptom prevalence within the cohort as the children matured while the burden of allergy symptoms increased.
尽管近年来哮喘和过敏的患病率有所增加，但传统上，哮喘的流行模式一直难以追踪。大多数关于儿童哮喘趋势的报告都是横断面研究，即在不同时间点测量相似年龄儿童队列中的患病率。本文旨在报告同一队列在两个不同时间点的症状患病率。
回顾性队列研究。
曼彻斯特市中心的社区研究。
MANCAS1 研究 n=5086，参与 n=2414。MANCAS2 研究 n=6338，参与 n=1608。在指定日期出生于曼彻斯特医院且仍居住或就读于曼彻斯特市中心学校的儿童有资格入选。在“高危”登记册上的儿童或与短期照顾者一起生活的儿童被排除在外。
使用家长完成的问卷在两个不同时间点收集呼吸症状数据。
MANCAS1 的应答率为 47.5%，MANCAS2 的应答率为 25.4%。有 801 人收到了两项研究的回复。在两个研究时间点之间，夜间咳嗽的患病率（29.5%比 18.3%，McNemar<0.01）和用于呼吸道感染的抗生素使用率（9.1%比 4.3%，McNemar<0.01）均显著降低。花粉症/湿疹的患病率增加（41.6%比 46.9%，McNemar<0.01）。喘息、运动诱发的喘息或哮喘药物的患病率没有显著差异。
尽管本报告在 7 年内同一人群在两个时间点的呼吸症状患病率显示哮喘症状负担持续存在，但随着儿童成熟，队列中哮喘症状的患病率存在一定的变化，而过敏症状的负担增加。
