Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL 60612, USA.
J Neuroimmune Pharmacol. 2012 Dec;7(4):731-9. doi: 10.1007/s11481-012-9411-y. Epub 2012 Oct 13.
Considerable studies have evaluated the interaction between Wnt/β-catenin signaling and numerous cellular processes. Emerging findings now demonstrate that Wnt/β-catenin signaling interacts with the life cycle of the Human Immunodeficiency Virus type 1 (HIV-1). Wnt/β-catenin is a restrictive pathway to HIV replication in multiple target cells including peripheral blood mononuclear cells and astrocytes. The molecular interaction between Wnt/β-catenin signaling and HIV has been evaluated in astrocytes because they express robust level of this pathway. The cross talk that occurs between these two components has significant biologic consequences to HIV-mediated neuropathogenesis. This perspective highlights current knowledge regarding the interaction between Wnt/β-catenin signaling and HIV, the interplay between these two pathways as it impacts key features of NeuroAIDS, and provides an assessment of knowledge gaps in the field that could propel our understanding of this interaction to inform novel strategies to exploit Wnt signaling for therapeutic intervention in HIV/NeuroAIDS.
大量研究评估了 Wnt/β-catenin 信号与许多细胞过程之间的相互作用。新出现的发现表明，Wnt/β-catenin 信号与人类免疫缺陷病毒 1 型（HIV-1）的生命周期相互作用。Wnt/β-catenin 是多种靶细胞包括外周血单核细胞和星形胶质细胞中 HIV 复制的限制性途径。已经在星形胶质细胞中评估了 Wnt/β-catenin 信号与 HIV 之间的分子相互作用，因为它们表达这种途径的强水平。这两个组件之间发生的串扰对 HIV 介导的神经发病机制具有重要的生物学后果。本观点强调了目前关于 Wnt/β-catenin 信号与 HIV 之间相互作用的知识，以及这两条途径相互作用对神经艾滋病的关键特征的影响，并评估了该领域的知识空白，这些空白可能会推动我们对这种相互作用的理解，为利用 Wnt 信号进行 HIV/神经艾滋病的治疗干预提供新策略。
