β-连环蛋白/TCF-4 信号通路在 HIV 复制和发病机制中的作用：为新型抗 HIV 分子治疗提供的启示。
Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
机构信息
Department of Immunology/Microbiology and Center for AIDS Research, Rush University Medical Center, Chicago, IL 60607, USA.
出版信息
J Neuroimmune Pharmacol. 2011 Jun;6(2):247-59. doi: 10.1007/s11481-011-9266-7. Epub 2011 Mar 8.
Abstract
A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.
摘要
深入了解 HIV 与宿主信号通路之间的相互作用，这些信号通路可以限制病毒的产生，从而可能为从潜伏储库中清除病毒并增强 HIV 靶向细胞的存活/功能找到新方法。这篇综述强调了 Wnt/β-连环蛋白通路作为一种宿主因子的作用，该因子可抑制多种靶细胞中的 HIV 复制，特别是与中枢神经系统中的 HIV 相关的靶细胞。
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