Couillard-Després Sébastien
Spinal Cord Injury and Tissue Regeneration Center Salzburg, Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020, Salzburg, Austria,
Curr Top Behav Neurosci. 2013;15:343-55. doi: 10.1007/7854_2012_232.
Although significant inconsistencies remain to be clarified, a role for neurogenesis in hippocampal functions, such as cognition, has been suggested by several reports. Yet, investigation in various species of mammals, including humans, revealed that rates of hippocampal neurogenesis are steadily declining with age. The very low levels of hippocampal neurogenesis persisting in the aged brain have been suspected to underlie the cognitive deficits observed in elderly. However, current evidence fails to support the hypothesis that decrease of neurogenesis along normal ageing leads to hippocampal dysfunction. Nevertheless, current studies are suggestive for a distinct role of hippocampal neurogenesis in young versus adult and old brain.
尽管仍有显著的不一致之处有待阐明，但几份报告已表明神经发生在海马体功能（如认知）中发挥作用。然而，对包括人类在内的各种哺乳动物的研究表明，海马体神经发生的速率会随着年龄的增长而稳步下降。老年大脑中持续存在的极低水平的海马体神经发生被怀疑是老年人认知缺陷的基础。然而，目前的证据并不支持神经发生随正常衰老而减少会导致海马体功能障碍这一假说。尽管如此，目前的研究表明海马体神经发生在幼年、成年和老年大脑中具有不同的作用。
