Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637616.
Chem Commun (Camb). 2012 Nov 25;48(91):11232-4. doi: 10.1039/c2cc36137j. Epub 2012 Oct 15.
Ruthenium- and rhodium-catalyzed direct oxidative cross-coupling reactions of acrylamides with alkenes were developed. These methods provide an efficient route for the synthesis of (Z,E)-dienamides in excellent yields with good stereoselectivity. The catalytic systems allowed oxidative olefination of a wide range of alkenes bearing different functional groups, such as CO(2)R, COMe, SO(2)Ph, aryl, CONHBn, CN, PO(OEt)(2), as well as Weinreb amide.
钌和铑催化的丙烯酰胺与烯烃的直接氧化交叉偶联反应得到了发展。这些方法为（Z，E）-二烯酰胺的合成提供了一条高效的途径，产率优异，立体选择性好。催化体系允许氧化烯化具有不同官能团的各种烯烃，如 CO(2)R、COMe、SO(2)Ph、芳基、CONHBn、CN、PO(OEt)(2)以及 Weinreb 酰胺。
