Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata (IDI-IRCCS), Rome, Italy.
J Invest Dermatol. 2012 Nov;132(11):2499-502. doi: 10.1038/jid.2012.369.
Fogo selvagem is an endemic form of pemphigus foliaceus (EPF) found in Brazil. Environmental and genetic factors are thought to contribute to the disease, which is associated with pathogenic IgG4 autoantibodies against the desmosomal cadherin desmoglein 1. In this issue, as an additional framework to understand autoimmune mechanisms in EPF, Flores et al. have investigated whether fogo selvagem patients and healthy individuals from endemic areas develop autoantibody responses against other desmosomal cadherins and E-cadherin.
野火烧不尽是一种在巴西发现的特发性落叶型天疱疮（EPF）。环境和遗传因素被认为与该病有关，该病与针对桥粒钙黏蛋白 1 的致病性 IgG4 自身抗体有关。在本期中，作为理解 EPF 中自身免疫机制的附加框架，Flores 等人研究了野火烧不尽患者和来自流行地区的健康个体是否会针对其他桥粒钙黏蛋白和 E-钙黏蛋白产生自身抗体反应。
