小窝蛋白-1在非小细胞肺癌抗失巢凋亡中的作用
Roles of caveolin-1 on anoikis resistance in non small cell lung cancer.
作者信息
Chunhacha Preedakorn, Chanvorachote Pithi
机构信息
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, and Cell-based Drug and Health Products Development Research Unit, Chulalongkorn, University Bangkok 10330, Thailand.
出版信息
Int J Physiol Pathophysiol Pharmacol. 2012;4(3):149-55. Epub 2012 Sep 20.
Abstract
Advance therapies which effectively reduce mortality in lung cancer patients become a global health challenge nowadays. Sufficient knowledge regarding cellular and molecular basis of cancer progression and metastasis would possibly help in the development of novel and effective strategies for the treatment of this disease. This review focuses on the information regarding the role and mechanism of caveolin-1 (Cav-1) protein on anoikis in Non Small Cell Lung Cancer (NSCLC). NSCLC accounts of approximately 80% of all diagnosed lung cancer cases which patients frequently presented with metastatic disease. Like other cancers, caveolin-1 (Cav-1) has been shown to play an important role in regulating cancer-cells behaviors including apoptosis resistance and metastasis. Even though further investigations as well as in vivo experiments are required, these data are of great interest and may be beneficial to the development of lung cancer therapy.
摘要
如今，能有效降低肺癌患者死亡率的先进疗法已成为一项全球性的健康挑战。关于癌症进展和转移的细胞及分子基础的充分知识，可能有助于开发治疗该疾病的新颖有效策略。本综述聚焦于小窝蛋白-1（Cav-1）蛋白在非小细胞肺癌（NSCLC）失巢凋亡中的作用及机制的相关信息。NSCLC约占所有确诊肺癌病例的80%，患者常出现转移性疾病。与其他癌症一样，小窝蛋白-1（Cav-1）已被证明在调节癌细胞行为（包括抗凋亡和转移）中起重要作用。尽管还需要进一步的研究以及体内实验，但这些数据极具吸引力，可能对肺癌治疗的发展有益。
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