癌症干细胞微环境的三维建模。

He Jun, Xiong Li, Li Qinglong, Lin Liangwu, Miao Xiongying, Yan Shichao, Hong Zhangyong, Yang Leping, Wen Yu, Deng Xiyun

Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

State Key Laboratory of Powder Metallurgy, Central South University, Changsha, Hunan, China.

Oncotarget. 2017 Aug 3;9(1):1326-1345. doi: 10.18632/oncotarget.19847. eCollection 2018 Jan 2.

Cancer stem cells reside in a distinct microenvironment called niche. The reciprocal interactions between cancer stem cells and niche contribute to the maintenance and enrichment of cancer stem cells. In order to simulate the interactions between cancer stem cells and niche, three-dimensional models have been developed. These culture systems recapitulate the spatial dimension, cellular heterogeneity, and the molecular networks of the tumor microenvironment and show great promise in elucidating the pathophysiology of cancer stem cells and designing more clinically relavant treatment modalites.

癌症干细胞存在于一种名为“生态位”的独特微环境中。癌症干细胞与生态位之间的相互作用有助于癌症干细胞的维持和富集。为了模拟癌症干细胞与生态位之间的相互作用，人们开发了三维模型。这些培养系统概括了肿瘤微环境的空间维度、细胞异质性和分子网络，在阐明癌症干细胞的病理生理学以及设计更具临床相关性的治疗方式方面显示出巨大潜力。