Endoh N, Oh H, Itoh K, Asai T, Yoshida S
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Eur J Haematol. 1990 Jan;44(1):45-50. doi: 10.1111/j.1600-0609.1990.tb00346.x.
We measured the calmodulin content in platelets in 13 normal persons and in 62 patients with hematological diseases. The level of platelet calmodulin was higher in patients with idiopathic thrombocytopenic purpura (ITP), systemic lupus erythematosus, myeloproliferative disorders, acute leukemia in a recovery phase, aplastic anemia, thrombosis and hypersplenism as compared to the controls. Among the patients with ITP, calmodulin was lower in responders than in nonresponders and those at the initial diagnosis. We also measured the volume, life-span and aggregation of the platelets and demonstrated a significant relationship between the calmodulin level and the platelet volume, and a negative relationship between the calmodulin level and platelet life-span, there was no correlation between the calmodulin level and platelet aggregation. We thus conclude that platelet calmodulin is inversely correlated with platelet turnover.
我们检测了13名正常人和62例血液病患者血小板中的钙调蛋白含量。与对照组相比，特发性血小板减少性紫癜（ITP）、系统性红斑狼疮、骨髓增殖性疾病、急性白血病恢复期、再生障碍性贫血、血栓形成和脾功能亢进患者的血小板钙调蛋白水平较高。在ITP患者中，有反应者的钙调蛋白低于无反应者和初诊患者。我们还检测了血小板的体积、寿命和聚集情况，结果表明钙调蛋白水平与血小板体积之间存在显著关系，与血小板寿命呈负相关，钙调蛋白水平与血小板聚集之间无相关性。因此，我们得出结论，血小板钙调蛋白与血小板周转率呈负相关。
