Baynes R D, Lamparelli R D, Bezwoda W R, Gear A J, Chetty N, Atkinson P
Department of Medicine, University of the Witwatersrand, Johannesburg.
S Afr Med J. 1988 Jan 9;73(1):39-43.
The relationship between mean platelet volume (MPV) and platelet count was evaluated in 259 patients with rheumatoid arthritis and 311 patients with various haematological disorders. Platelet volume-number relationships determined in a previous study on normal subjects were used as a reference range. There was a significant inverse relationship between MPV and platelet count in patients with rheumatoid arthritis (r = -0.49; P less than 0.0001), which by interval analysis was shown to be non-linear. In the patients with haematological disorders, the platelets were found to be disproportionately small for number in patients with aplastic anaemia, chemotherapy-induced marrow suppression and some cases of acute idiopathic thrombocytopenic purpura (ITP). In subjects with chronic ITP followed longitudinally, the inverse platelet volume-number relationship was retained. MPV was appropriate for platelet number in myelodysplastic syndromes, variable in iron deficiency anaemia and disproportionately large in myeloproliferative syndromes, most notably in agnogenic myeloid metaplasia. The observation that the MPV was disproportionately large in comparison with the platelet count was used in establishing the diagnosis of an hereditary giant platelet syndrome in a family of British origin.
在259例类风湿性关节炎患者和311例各种血液系统疾病患者中评估了平均血小板体积（MPV）与血小板计数之间的关系。将先前一项针对正常受试者的研究中确定的血小板体积-数量关系用作参考范围。类风湿性关节炎患者的MPV与血小板计数之间存在显著的负相关关系（r = -0.49；P小于0.0001），通过区间分析显示这种关系是非线性的。在血液系统疾病患者中，发现再生障碍性贫血、化疗引起的骨髓抑制以及一些急性特发性血小板减少性紫癜（ITP）病例的患者，其血小板数量与体积不成比例地小。在纵向随访的慢性ITP患者中，血小板体积-数量的负相关关系依然存在。在骨髓增生异常综合征中，MPV与血小板数量相符；在缺铁性贫血中，MPV有所变化；而在骨髓增殖性综合征中，MPV与血小板数量不成比例地大，最显著的是在原因不明的髓样化生中。在一个英裔家族中，通过观察到MPV与血小板计数相比不成比例地大，从而确立了遗传性巨大血小板综合征的诊断。
