Sood Ajit, Sarin Shiv Kumar, Midha Vandana, Hissar Syed, Sood Neena, Bansal Pankaj, Bansal Manu
Department of Gastroenterology, Dayanand Medical College, Tagore Nagar, Civil Lines, Ludhiana, 141 001, India.
Indian J Gastroenterol. 2012 Sep;31(5):232-6. doi: 10.1007/s12664-012-0251-8. Epub 2012 Oct 17.
Epidemiological data on hepatitis C virus (HCV) infection from India are scanty. We conducted a population-based seroepidemiologic survey to estimate the prevalence of hepatitis C in Punjab state of northern India.
A house-to-house survey was conducted in a defined population of 26,273 subjects. Information was gathered according to a predesigned questionnaire with socio-demographic characteristics (age, gender and substance abuse), family history of HCV infection, general health status, associated co-infection, immunization history and potential risk factors for HCV transmission. At the time of clinical evaluation, blood was tested for anti-HCV and those found positive were tested for HCV RNA.
Among 5,258 subjects screened, 272 were found to be anti-HCV positive (prevalence rate of 5.2 %); highest prevalence being noticed in 41-60 years age group. Anti-HCV positive rate were not different among males and females. Sixty-seven subjects (1.3 %) were found to be HBsAg positive; four of these being co-infected (5.9 %). Various risk factors for acquiring HCV infection identified were history of surgery, dental treatment and unprotected sex. Other associations were strong family history of HCV positivity, alcohol consumption and diabetes mellitus.
Chronic HCV infection is a major health problem in Punjab; it appears to be more common than HBV infection. Exercising safe health care related procedures should be emphasized in our country as main modes of transmission of infection identified were related to these.
来自印度的丙型肝炎病毒（HCV）感染的流行病学数据匮乏。我们开展了一项基于人群的血清流行病学调查，以估计印度北部旁遮普邦丙型肝炎的患病率。
在26273名特定人群中进行了挨家挨户的调查。根据预先设计的问卷收集信息，内容包括社会人口学特征（年龄、性别和药物滥用情况）、HCV感染家族史、总体健康状况、合并感染情况、免疫史以及HCV传播的潜在危险因素。在临床评估时，检测血液中的抗HCV，检测出阳性者再检测HCV RNA。
在5258名接受筛查的受试者中，发现272人抗HCV呈阳性（患病率为5.2%）；41 - 60岁年龄组的患病率最高。男性和女性的抗HCV阳性率无差异。发现67名受试者（1.3%）HBsAg呈阳性；其中4人合并感染（5.9%）。确定的感染HCV的各种危险因素包括手术史、牙科治疗史和无保护性行为。其他相关因素包括HCV阳性的强烈家族史、饮酒和糖尿病。
慢性HCV感染是旁遮普邦的一个主要健康问题；它似乎比HBV感染更常见。由于已确定的主要感染传播途径与这些因素有关，因此在我国应强调实施安全的医疗保健相关程序。
