Computational Medicine Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Bioinformatics. 2012 Dec 15;28(24):3322-3. doi: 10.1093/bioinformatics/bts615. Epub 2012 Oct 16.
MicroRNA (miRNA) target prediction is an important problem. Given an miRNA sequence the task is to determine the identity of the messenger RNAs targeted by it, the locations within them where the interactions happen and the specifics of the formed heteroduplexes. Here, we describe a web-based application, RNA22-GUI, which we have designed and implemented for the interactive exploration and in-context visualization of predictions by RNA22, one of the popular miRNA target prediction algorithms. Central to our design has been the requirement to provide informative and comprehensive visualization that is integrated with interactive search capabilities and permits one to selectively isolate and focus on relevant information that is distilled on-the-fly from a large repository of pre-compiled predictions. RNA22-GUI is currently available for Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans.
miRNA（微 RNA）靶标预测是一个重要问题。给定一个 miRNA 序列，任务是确定其靶向的信使 RNA 的身份、它们内部发生相互作用的位置以及形成的异源双链体的具体情况。在这里，我们描述了一个基于网络的应用程序 RNA22-GUI，我们为其设计并实现了用于交互探索和上下文可视化的功能，该应用程序是流行的 miRNA 靶标预测算法之一 RNA22 的一部分。我们的设计的核心是提供信息丰富和全面的可视化，与交互式搜索功能集成，并允许用户选择性地隔离和关注从大型预编译预测存储库中即时提取的相关信息。RNA22-GUI 目前可用于智人、小家鼠、黑腹果蝇和秀丽隐杆线虫。
