Fondazione Ri.MED, 90133 Palermo, Italy.
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W159-64. doi: 10.1093/nar/gkt379. Epub 2013 May 22.
ComiR is a web tool for combinatorial microRNA (miRNA) target prediction. Given an messenger RNA (mRNA) in human, mouse, fly or worm genomes, ComiR computes the potential of being targeted by a set of miRNAs, each of which can have zero, one or more targets on its 3'untranslated region. In determining the regulatory potential of an mRNA from a set of miRNAs, ComiR uses user-provided miRNA expression levels in a combination of appropriate thermodynamic modeling and machine learning techniques to make more accurate predictions. For each gene, ComiR returns the probability of being a functional target of a set of miRNAs, which depends on the relative miRNA expression levels. The tool provides a user-friendly interface to input a miRNA expression table containing many sample information and filter out the most relevant miRNAs. ComiR results can be downloaded or visualized on a table, which can then be used to select the most relevant targets and to compare the results obtained with different miRNA expression input. ComiR is freely available for academic use at http://www.benoslab.pitt.edu/comir/.
ComiR 是一个用于组合 microRNA（miRNA）靶标预测的网络工具。给定人类、老鼠、苍蝇或蠕虫基因组中的信使 RNA（mRNA），ComiR 计算一组 miRNA 靶向的可能性，其中每个 miRNA 在其 3'非翻译区可以有零个、一个或多个靶标。在确定一组 miRNA 中一个 mRNA 的调节潜力时，ComiR 使用用户提供的 miRNA 表达水平，结合适当的热力学建模和机器学习技术，以做出更准确的预测。对于每个基因，ComiR 返回一组 miRNA 的功能靶标的概率，这取决于相对的 miRNA 表达水平。该工具提供了一个用户友好的界面，用于输入包含许多样本信息的 miRNA 表达表，并过滤出最相关的 miRNA。ComiR 的结果可以下载或在表格上可视化，然后用于选择最相关的靶标，并比较不同 miRNA 表达输入获得的结果。ComiR 可在 http://www.benoslab.pitt.edu/comir/ 上免费用于学术用途。
